RT Journal Article
T1 Sucrosomial® Iron: An Updated Review of Its Clinical Efficacy for the Treatment of Iron Deficiency.
A1 Gómez-Ramírez, Susana
A1 Brilli, Elisa
A1 Tarantino, Germano
A1 Girelli, Domenico
A1 Muñoz-Gómez, Manuel
K1 Anemia - Tratamiento
K1 Hierro - Uso terapéutico - Ensayos
AB Iron deficiency (ID) and iron deficiency anemia (IDA) are highly prevalent worldwide.Oral iron salts, especially ferrous sulfate, are commonly used for the treatment of iron deficiency (ID).However, its use is associated with gastrointestinal side effects, thus compromising treatment com pliance. Intravenous iron administration is a more costly and logistically complex alternative andis not risk-free, as infusion and hypersensitivity reactions may occur. Sucrosomial® iron is an oralformulation consisting of ferric pyrophosphate conveyed by a phospholipid and sucrester matrix(sucrosome®). Intestinal Sucrosomial® iron absorption is mediated by enterocytes and M cells,through the paracellular and transcellular routes, and occurs mostly as intact particles. These phar macokinetic properties of Sucrosomial® iron result in higher iron intestinal absorption and excellentgastrointestinal tolerance compared to oral iron salts. The evidence derived from clinical studiessupports the use of Sucrosomial® iron as a valid first option for the treatment of ID and IDA, espe cially for subjects who are intolerant or refractory to conventional iron salts. Newer evidence alsodemonstrates the effectiveness of Sucrosomial® iron, with a lower cost and fewer side effects, incertain conditions usually treated with IV iron in current clinical practice
PB MDPI
YR 2023
FD 2023-06-06
LK https://hdl.handle.net/10630/27139
UL https://hdl.handle.net/10630/27139
LA eng
NO Gómez-Ramírez S, Brilli E, Tarantino G, Girelli D, Muñoz M. Sucrosomial® Iron: An Updated Review of Its Clinical Efficacy for the Treatment of Iron Deficiency. Pharmaceuticals. 2023; 16(6):847. https://doi.org/10.3390/ph16060847
NO Partial funding for open access charge: Universidad de Málaga
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 10 feb 2026