RT Journal Article
T1 Influence of the microbiome on radiotherapy-induced oral mucositis and its management: A comprehensive review
A1 Fernández Forné, África
A1 García Anaya, María Jesús
A1 Segado Guillot, Salvador José
A1 Plaza-Andrades, Isaac
A1 De-la-Peña-Fernández, Lourdes
A1 Lorca Ocón, María Jesús
A1 Lupiáñez Pérez, Yolanda
A1 Queipo-Ortuño, María Isabel
A1 Gómez-Millán Barrachina, Jaime
K1 Boca - Cáncer
K1 Radioterapia - Complicaciones y secuelas
K1 Mucosa oral - Enfermedades
AB Radiation-induced mucositis is the most common, debilitating and painful acute toxicity associated with active treatment in head and neck cancer area, severely affecting more than 65% of patients. Oral microbiota significantly changes during cancer therapy and appears to be involved on its pathophysiology. This review aims to present a comprehensive update of new etiopathogenic factors and treatments that may decrease the incidence of mucositis, mainly modifications of dietary interventions to modify microbiome. Despite advances in recent years, its management is mainly symptomatic opioid-based with variable results on different substances analyzed for its prevention. Immunonutrition seems to play a significant role, particularly the supplementation of compounds such as fatty acids, polyphenols or selected probiotics have shown to promote commensal bacteria diversity and reduced incidence of ulcerative mucositis. Modification of the microbiome is a promising preventive treatment for mucositis although its evidence is still scarce. Large studies are needed to demonstrate the efficacy of interventions on microbiome and its clinical impact on radiation-induced mucositis.
PB Elsevier
YR 2023
FD 2023-07
LK https://hdl.handle.net/10630/27200
UL https://hdl.handle.net/10630/27200
LA eng
NO Fernández Forné Á, García Anaya MJ, Segado Guillot SJ, Plaza Andrade I, de la Peña Fernández L, Lorca Ocón MJ, Lupiáñez Pérez Y, Queipo-Ortuño MI, Gómez-Millán J. Influence of the microbiome on radiotherapy-induced oral mucositis and its management: A comprehensive review. Oral Oncol. 2023 Jul 1;144:106488. doi: 10.1016/j.oraloncology.2023.106488.
NO Funding for open access charge: Universidad de Málaga / CBUA.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 24 ene 2026