RT Journal Article
T1 Resting-state functional connectivity alterations in post-stroke cognitive impairment: a systematic review
A1 Sagues, Elena
A1 Alfaro, Francisco
A1 Ramos-Rodríguez, Ramón
A1 García-Casares, Natalia
K1 Cerebro - Enfermedades - Complicaciones y secuelas
K1 Redes neuronales (Neurobiología)
AB Post-stroke cognitive impairment is a common and highly disabling multi-domain cognitive decline with unclear pathophysiological mechanisms. Its extent may be predicted by functional neuroimaging techniques, which could enhance our understanding of its underlying pathophysiology. Synthesize the state-of-the-art knowledge on resting-state functional magnetic resonance imaging findings in post-stroke cognitive impairment, their correlation with cognitive performance and the secondary compensatory connectivity changes. We performed a qualitative systematic literature review of reported data of resting-state functional magnetic resonance imaging abnormalities in post-stroke cognitive impairment, consulting the electronic databases Medline, Scopus, Web of Science, Cochrane, and BASE until June 2024. We selected 23 studies. They reported several key brain areas and network abnormalities associated with post-stroke cognitive impairment compared to controls and non-demented patients. The main areas with decreased functional connectivity were the medial prefrontal cortex, the inferior frontal gyrus, the posterior and anterior cingulate cortex, the precuneus and the hippocampus. The principal network altered was the default mode network, which includes the majority of the brain structures previously mentioned. Additionally, increased functional connectivity in other contralesionally areas may represent maladaptive or compensatory changes post-stroke. Resting-state functional magnetic resonance imaging is a promising tool for studying functional changes associated with post-stroke cognitive impairment. It may enhance our understanding of its pathophysiology and improve selection of suitable period or candidates for cognitive rehabilitation.
PB Springer Nature
SN 1931-7557
YR 2025
FD 2025-06-04
LK https://hdl.handle.net/10630/38900
UL https://hdl.handle.net/10630/38900
LA eng
NO Sagues, E., Alfaro, F., Ramos-Rodríguez, R. et al. Resting-state functional connectivity alterations in post-stroke cognitive impairment: a systematic review. Brain Imaging and Behavior (2025). https://doi.org/10.1007/s11682-025-01013-w
NO Funding for open access charge: Universidad de Málaga / CBUA
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026