RT Journal Article
T1 A comparative study of the antiangiogenic activity of hydroxytyrosyl alkyl ethers
A1 Marrero Capitán, Ana Dácil
A1 Castilla, Laura
A1 Espartero Sánchez, José Luis
A1 Madrona, Andrés
A1 Rodríguez-Quesada, Ana María
A1 Medina-Torres, Miguel Ángel
A1 Martínez-Póveda, Beatriz Amparo
K1 Neovascularización
K1 Aceite de oliva
AB The phenolic compound hydroxytyrosol and its derivatives are responsible for some of the health benefits of theintake of virgin olive oil, having shown antiangiogenic properties. In this study, we explored the antiangiogenicpotential of six synthetic hydroxytyrosyl alkyl ethers (HT C1, C2, C4, C6, C8 and C12). Our results showed thatall compounds affected endothelial cell viability in vitro at low micromolar doses. In addition, compounds HT C1,C2, C4 and C6 inhibited endothelial cell migration and formation of tubular-like structures. In these assays,hydroxytyrosyl hexyl ether (HT C6) exhibited the most potent inhibitory activity in vitro, activating as wellapoptosis in endothelial cells. Furthermore, the antiangiogenic activity of HT C6 was confirmed in vivo in thechick chorioallantoic membrane assay. Hence, we present hydroxytyrosol synthetic derivative HT C6 as a newantiangiogenic compound and as a good candidate for an antiangiogenic drug in the treatment of angiogenesisdependentdiseases.
YR 2020
FD 2020-09-22
LK https://hdl.handle.net/10630/19821
UL https://hdl.handle.net/10630/19821
LA eng
NO Versión preprint del manuscrito de los autores, publicado finalmente en: Food Chemistry 333 (2020) 127476 con DOI: 10.1016/j.foodchem.2020.127476
NO This work was supported by the Spanish Ministry of Science,Innovation and Universities (grants AGL2007-66373 and PID2019-105010RB-I00), Andalusian Government and FEDER (P12-CTS-1507,UMA18-FEDERJA-220 and funds from group BIO 267), as well as fundsfrom the University of Málaga (“Plan Propio de Investigación yTransferencia”). The “CIBER de Enfermedades Raras” and “CIBER deEnfermedades Cardiovasculares” are initiatives from the ISCIII (Spain).The funders had no role in the study design, data collection and analysis,decision to publish or preparation of the manuscript.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026