RT Journal Article
T1 ANK3-dependent SVZ niche assembly is required for the continued production of new neurons.
A1 Páez-González, Patricia
A1 Abdi, Khadar
A1 Dominic, Luciano
A1 Liu, Yan
A1 Soriano-Navarro, Mario
A1 Rawlins, Emma
A1 Bennet, Vann
A1 Garcia-Verdugo, José
A1 Kuo, Chay T.
K1 Neurobiología del desarrollo
K1 Células madre neurales
AB The rodent subventricular/subependymal zone (SVZ/SEZ) houses neural stem cells (NSCs) that generate olfactory bulb interneurons. It is unclear how the SVZ environment sustains neuronal production into adulthood. We discovered that the adapter molecule Ankyrin-3 (Ank3) is specifically upregulated in ventricular progenitors destined to become ependymal cells, but not in NSCs, and is required for SVZ niche assembly through progenitor lateral adhesion. Furthermore, we found that Ank3 expression is controlled by Foxj1, a transcriptional regulator of multicilia formation, and genetic deletion of this pathway led to complete loss of SVZ niche structure. Interestingly, radial glia continued to transition into postnatal NSCs without this niche. However, inducible deletion of Foxj1-Ank3 from mature SVZ ependyma resulted in dramatic depletion of neurogenesis. Targeting a pathway regulating ependymal organization/assembly and showing its requirement for new neuron production, our results have important implications for environmental control of adult neurogenesis and harvesting NSCs for replacement therapy.
PB Cell Press
YR 2011
FD 2011-07-14
LK https://hdl.handle.net/10630/40101
UL https://hdl.handle.net/10630/40101
LA eng
NO Paez-Gonzalez P, Abdi K, Luciano D, Liu Y, Soriano-Navarro M, Rawlins E, Bennett V, Garcia-Verdugo JM, Kuo CT. Ank3-dependent SVZ niche assembly is required for the continued production of new neurons. Neuron. 2011 Jul 14;71(1):61-75. doi: 10.1016/j.neuron.2011.05.029. PMID: 21745638; PMCID: PMC3134799.
NO https://openpolicyfinder.jisc.ac.uk/id/publication/6589
NO National Institut of Health (USA)
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026