RT Conference Proceedings
T1 Evaluation of the anti-angiogenic potential of hydroxytyrosol derivatives
A1 Marrero Capitán, Ana Dácil
A1 Martínez-Póveda, Beatriz Amparo
A1 Castilla, Laura
A1 Gallardo, Elena
A1 Espartero Sánchez, José Luis
A1 Carrillo Fernández, Paloma
A1 Rodríguez-Quesada, Ana María
A1 Medina-Torres, Miguel Ángel
K1 Neovascularización
K1 Biología molecular
AB Angiogenesis, a process which allows the formation of new vessels from pre-existing ones, is an essential phenomenon for tumor survival since it allows cancer cells to obtain nutrients and oxygen. This explains the increasing interest showed by many groups of research and pharmaceutical companies to find compounds with potential to disrupt at least one of the steps within the angiogenic process. Hydroxytyrosol (3,4-dihydroxyphenyl ethanol) has been identified as the most important health-related phenolic compound of virgin olive oil because of its pleiotropic effects on multiple targets. In 2012, our group identified hydroxytyrosol as an anti-angiogenic compound able to inhibit several key steps in the angiogenic process. In the present study, the potential effects of six hydroxytyrosol derivatives are tested and compared with those exhibited by hydroxytyrosol by making use of several in vitro and in vivo assays. Results indicate that these are candidate new anti-angiogenic compounds with potential utility in anti-tumor and anti-angiogenic therapies.
YR 2018
FD 2018-09-19
LK https://hdl.handle.net/10630/16495
UL https://hdl.handle.net/10630/16495
LA eng
NO Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech[Our experimental work is supported by grants BIO2014-56092-R (MINECO and FEDER) and P12-CTS-1507 (Andalusian Government and FEDER) and funds from group BIO-267 (Andalusian Government). The "CIBER de Enfermedades Raras" is an initiative from the ISCIII (Spain)]. This communication has the support of a travel grant.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 25 ene 2026