RT Journal Article
T1 Exploring Marine-Derived Polysaccharides Through In Vitro and Zebrafish In Vivo Assays: Initial Trends of A Novel Approach to Drug Screening
A1 Latorre-Redoli, Sofía
A1 Valverde-Guillén, Piedad
A1 García-Márquez, Jorge
A1 López-Figueroa, Félix
A1 Abdala-Díaz, Roberto Teófilo
A1 Mari-Beffa, Manuel
K1 Acuicultura
K1 Polisacáridos
K1 Peces cebra
AB The sulfated polysaccharides derived from marine species have attracted attention for their nutraceutical and pharmaceutical potential. Initially examined in cell culture, many labs have further tested their activity in in vivo rodent assays. Zebrafish embryos have been recently proposed as an alternative model species to test anti-inflammatory, fungicidal, immunomodulatory, antioxidant, antitumor or toxicity effects with significant success. In this article, we systematically review by PRISMA strategy the assays that use zebrafish to evaluate potential nutraceutical and pharmaceutical applications of polysaccharides from more than 30 marine algal species. Effects against cancer, inflammation and oxidative stress or over regeneration capacity, immunomodulation, and photoprotection in zebrafish are here compared. From this review, some polysaccharides appear as safe antitumor compounds (e.g., neutral S. skottsbergii-derived fraction over G-361 melanoma) while others show significant toxicity to embryos. The current bibliography shows a clear trend to use in parallel zebrafish larvae and in vitro assays to test the effects of polysaccharide fractions recovered from a variety of bioprocess from different marine algae-derived biomass. Its potential application in the pharmacology and nutraceutical industry is discussed.
PB Springer Nature
YR 2025
FD 2025-11-24
LK https://hdl.handle.net/10630/40924
UL https://hdl.handle.net/10630/40924
LA eng
NO Latorre-Redoli, S., Valverde-Guillén, P., García-Márquez, J., Figueroa, F.L., Abdala-Díaz, R., Marí Beffa, M. (2025) Exploring Marine-Derived Polysaccharides Through In Vitro and Zebrafish In Vivo Assays: Initial Trends of A Novel Approach to Drug Screening. Marine Biotechnology (en prensa)
NO https://openpolicyfinder.jisc.ac.uk/id/publication/16140
NO NextGenerationEU
NO Junta de Andalucía
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026