RT Journal Article
T1 Molecular and cellular characterization of the age-related neuroinflammatory processes occurring in normal rat hippocampus: potential relation with the loss of somatostatin GABAergic neurons.
A1 Gavilán, M. Paz
A1 Revilla, Elisa
A1 Pintado, Cristina
A1 Castaño, Angélica
A1 Vizuete, María Luisa
A1 Moreno-González, Inés
A1 Baglietto-Vargas, David
A1 Sánchez-Varo, Raquel María
A1 Vitorica Ferrández, Javier
A1 Gutiérrez-Pérez, Antonia
A1 Ruano, Diego
K1 Sistema nervioso - Degeneración
K1 Neuroglia
K1 Sistema nervioso - Inflamación
K1 Envejecimiento
K1 Hipocampo (Cerebro)
K1 Somatostatina
AB Increased neuroinflammatory reaction is frequently observedduring normal brain aging. However, a direct link betweenneuroinflammation and neurodegeneration during aging has notyet been clearly shown. Here, we have characterized the agerelated hippocampal inflammatory processes and the potentialrelation with hippocampal neurodegeneration. The mRNAexpression of the pro-inflammatory cytokines IL-1b and tumornecrosis factor-a (TNF-a), and the iNOs enzyme was significantly increased in aged hippocampus. Accordingly, numerousactivated microglial cells were observed in aged rats. Thesecells were differentially distributed along the hippocampus,being more frequently located in the hilus and the CA3 area. ThemRNA expression of somatostatin, a neuropeptide expressedby some GABAergic interneurons, and the number of somatostatin-immunopositive cells decreased in aged rats. However,the number of hippocampal parvalbumin-containing GABAergicinterneurons was preserved. Interestingly, in aged rats, themRNA expression of somatostatin and IL-1b was inverselycorrelated and, the decrease in the number of somatostatinimmunopositive cells was higher in the hilus of dentate gyrusthan in the CA1 region. Finally, intraperitoneal chronic lipopolysaccharide (LPS) injection in young animals mimicked the agerelated hippocampal inflammation as well as the decrease ofsomatostatin mRNA expression. Present results strongly support the neuroinflammation as a potential factor involved in theage-related degeneration of somatostatin GABAergic cells.
PB Wiley
YR 2007
FD 2007-06-29
LK https://hdl.handle.net/10630/36530
UL https://hdl.handle.net/10630/36530
LA eng
NO Gavilán MP, Revilla E, Pintado C, Castaño A, Vizuete ML, Moreno-González I, Baglietto-Vargas D, Sánchez-Varo R, Vitorica J, Gutiérrez A, Ruano D. Molecular and cellular characterization of the age-related neuroinflammatory processes occurring in normal rat hippocampus: potential relation with the loss of somatostatin GABAergic neurons. J Neurochem. 2007 Nov;103(3):984-96. doi: 10.1111/j.1471-4159.2007.04787.x. Epub 2007 Jul 31. PMID: 17666053.
NO https://openpolicyfinder.jisc.ac.uk/id/publication/3653
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 22 ene 2026