RT Journal Article
T1 Genetic ablation of tau mitigates cognitive impairment induced by type 1 diabetes
A1 Abbondante, Serena
A1 Baglietto-Vargas, David
A1 Rodriguez-Ortiz, Carlos J
A1 Estrada-Hernandez, Tatiana
A1 Medeiros, Rodrigo
A1 LaFerla, Frank
K1 Diabetes
AB Patients affected by diabetes show an increased risk of developing Alzheimer disease (AD). Similarly,patients with AD show impaired insulin function and glucose metabolism. However, the underlying molecular mechanisms connecting these two disorders are still not well understood. Herein, we investigatedthe microtubule-associated protein tau as a new link between AD and diabetes. To determine whetherdiabetes causes cognitive decline by a tau-dependent mechanism, we treated non-transgenic (Ntg) and tauknockout mice with streptozotocin, causing type 1 diabetes-like disease (T1D). Interestingly, althoughinduction of T1D in Ntg mice led to cellular and behavioral deficits, it did not do so in tau-knockout mice.Thus, data suggest that tau is a fundamental mediator of the induction of cognitive impairments in T1D. Taudysregulation, which causes a reduction in synaptic protein levels, may be responsible for the cognitivedecline observed in Ntg streptozotocin-treated mice. Concomitantly, we demonstrate the novel finding thatdepletion of endogenous tau mitigates behavioral impairment and synaptic deficits induced in T1D-likemice. Overall, our data reveal that tau is a key molecular factor responsible for the induction of cognitivedeficits observed in T1D and represents a potential therapeutic target for diabetes and patients with AD.
PB Elsevier
YR 2014
FD 2014-03
LK https://hdl.handle.net/10630/34442
UL https://hdl.handle.net/10630/34442
LA eng
NO Serena Abbondante, David Baglietto-Vargas, Carlos J. Rodriguez-Ortiz, Tatiana Estrada-Hernandez, Rodrigo Medeiros, Frank M. LaFerla, Genetic Ablation of Tau Mitigates Cognitive Impairment Induced by Type 1 Diabetes, The American Journal of Pathology, Volume 184, Issue 3, 2014, Pages 819-826, ISSN 0002-9440, https://doi.org/10.1016/j.ajpath.2013.11.021
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026