RT Journal Article
T1 A Distinct Metabolite Profile Correlates with Neurodegenerative Conditions and the Severity of Congenital Hydrocephalus
A1 Garcia-Bonilla, María
A1 Garcia-Leon, Maria L
A1 Muñoz-Hernandez, M Carmen
A1 Domínguez-Pinos, Dolores
A1 Martínez-León, María Isabel
A1 Peñalver, Ana
A1 Castilla, Ana
A1 Alonso, Francisco J
A1 Marquez, Javier
A1 Shumilov, Kirill
A1 Hidalgo-Sanchez, Ramon
A1 Gutiérrez-Pérez, Antonia
A1 Páez-González, Patricia
A1 Jimenez, Antonio J
K1 Hidrocefalia
K1 Líquido cefalorraquídeo
AB In congenital hydrocephalus, cerebrospinal fluid accumulation is associated with increased intracranial pressure (ICP), ischemia/hypoxia, metabolic impairment, neuronal damage, and astrocytic reaction. The aim of this study was to identify whether a metabolite profile revealing tissue responses according to the severity of hydrocephalus can be detected. The hyh mutant mouse used for this study exhibits 2 different forms of hydrocephalus, severe and moderate. In a comprehensive investigation into the 2 progressions of hydrocephalus, mice with severe hydrocephalus were found to have higher ICP and astrocytic reaction. Several metabolites from the mouse brain cortex were analyzed with 1H high-resolution magic angle spinning nuclear magnetic resonance (1H HR-MAS NMR) spectroscopy. A differential profile for metabolites including glutamate and glutamine was found to correlate with the severity of hydrocephalus and can be explained due to differential astrocytic reactions, neurodegenerative conditions, and the presence of ischemia. The glutamate transporter EAAT2 and the metabolite taurine were found to be key histopathological markers of affected parenchymata. In conclusion, a differential metabolite profile can be detected according to the severity of hydrocephalus and associated ICP and therefore can be used to monitor the efficacy of experimental therapies.
PB Oxford Academic
YR 2018
FD 2018-12-01
LK https://hdl.handle.net/10630/45889
UL https://hdl.handle.net/10630/45889
LA eng
NO María García-Bonilla, María L García-Martín, M Carmen Muñoz-Hernández, Dolores Domínguez-Pinos, María I Martínez-León, Ana Peñalver, Laura Castilla, Francisco J Alonso, Javier Márquez, Kirill Shumilov, Ramón Hidalgo-Sánchez, Antonia Gutiérrez, Patricia Páez-González, Antonio J Jiménez, A Distinct Metabolite Profile Correlates with Neurodegenerative Conditions and the Severity of Congenital Hydrocephalus, Journal of Neuropathology & Experimental Neurology, Volume 77, Issue 12, December 2018, Pages 1122–1136, https://doi.org/10.1093/jnen/nly097
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 21 mar 2026