RT Journal Article
T1 Gut Microbiota-specific Profile Prior to Surgery for Predicting Type 2 Diabetes Remission in Patients Undergoing Sleeve Gastrectomy
A1 Martínez-Montoro, José Ignacio
A1 Sancho-Marín, Raquel
A1 Garrido-Sánchez, Lourdes
A1 Ocaña-Wilhelmi, Luis Tomás
A1 Soler-Humanes, Rocío
A1 Ruiz-Campos, Nerea
A1 García-López, María José
A1 Tinahones-Madueño, Francisco José
A1 Gutiérrez-Repiso, Carolina
K1 Diabetes tipo 2
AB Objective The predictive role of baseline gut microbiota in type 2 diabetes (T2D) remission after bariatric surgery remainsunexplored. This study aimed to identify specific gut microbiota profiles prior to surgery associated with T2D remission fol-lowing sleeve gastrectomy (SG).Methods This was an observational study including participants with a body mass index (BMI) ≥ 40 kg/m2 and T2D whounderwent SG, and had preoperative stool samples available. Gut microbiota was analayzed by 16 S rRNA sequencing. Par-ticipants were classified into remission and non-remission groups based on T2D status one year after SG.Results A total of forty-six participants were included. After adjusting for baseline confounders (i.e., age, HbA1c levels,T2D duration, and insulin treatment), preoperative gut microbiota diversity showed no statistically significant differencesbetween groups, except for Pielou’s evenness index, which was significantly higher in the non-remission group (p = 0.01).ANCOM-BC2 analysis identified an enrichment in Fusicatenibacter, Holdemanella and Senegalimassilia in the non-remis-sion group, whereas Eggerthella, Flavonifractor, Ruminococcaceae g__Incertae Sedis and Ruminococcus gnavus groupwere enriched in the remission group. Furthermore, insulin treatment and the gut microbial taxa Ruminococcaceae g__Incer-tae Sedis, Fusicatenibacter, and Eggerthella emerged as potential predictors of T2D remission. Functional analysis usingPICRUSt2 revealed increased carbohydrate metabolism pathways in the remission group.Conclusions Baseline gut microbiota composition may serve as an independent predictor of T2D remission in patientsundergoing SG, and could become a potentially relevant biomarker, complementing other existing clinical predictors.
PB Springer
YR 2026
FD 2026-03
LK https://hdl.handle.net/10630/46239
UL https://hdl.handle.net/10630/46239
LA eng
NO Martínez-Montoro, J., Sancho-Marín, R., Garrido-Sánchez, L. et al. Gut Microbiota-specific Profile Prior to Surgery for Predicting Type 2 Diabetes Remission in Patients Undergoing Sleeve Gastrectomy. OBES SURG (2026). https://doi.org/10.1007/s11695-026-08612-6
NO Funding for open access charge: Universidad de Málaga / CBUA
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 8 abr 2026