RT Journal Article
T1 Mesenteric adipose tissue in Crohn’s disease alters the immune response of the ileal mucosa and increases angiogenesis and fibrosis.
A1 Reyes Martín, Flores
A1 Kentaoui-Bousellam, Imane
A1 Ruíz-Malagón, Antonio Jesús
A1 Ho-Plágaro, Ailec
A1 López-Gómez, Carlos
A1 Herraiz-Vilela, Marina
A1 Alcaín-Martínez, Guillermo
A1 Camargo-Camero, Raquel
A1 Martos-VanDussen, Juan Víctor
A1 Camacho-Martel, Laura
A1 Gutiérrez-Martínez, Fernando
A1 Arranz-Salas, Isabel
A1 Ortega-Jiménez, María Victoria
A1 Escamilla Sánchez, Alejandro
A1 Daza-González, Juan José
A1 Sanchiz-Cárdenas, Elena
A1 Rivas-Becerra, José
A1 García Fuentes, Eduardo
A1 Rodríguez Pacheco, Francisca
A1 Rodríguez-Díaz, Cristina
K1 Inmunopatología
K1 Respuesta inmune
K1 Neovascularización
K1 Enteritis regional
K1 Enfermedad inflamatoria intestinal
K1 Tejido adiposo
AB Mesenteric adipose tissue (MAT) may be involved in the pathogenesis of Crohn's disease (CD). However, its precise role remains uncertain. We analize the profile of molecules secreted by the MAT (secretome) in CD, differentiating between 'creeping fat' (CD-CrF) and the MAT obtained from a non-affected area (CD-NA), and to characterise its impact on the healthy ileum. The immune cell infiltration was higher in MAT from CD, particularly in CrF, compared to control-MAT. CD-NA and CD-CrF secretomes exhibited an increase of cytokines, immuno-checkpoints and other serum markers. A second profile included an increase in growth factors only in CD-CrF secretome. CD-NA and CD-CrF secretomes demonstrated enhanced myofibroblast wound healing and endothelial cell tube formation. On healthy human ileum, CD-NA and CD-CrF secretomes led to a down-regulation of genes related to antigen presentation to T cells, the major histocompatibility complex class II and the Th2 and Th17 cell differentiation. In conclusion, the profile of MAT secretome is different in CD patients, and their effects on the ileum, specially those of CrF, suggest a modification of the adaptive immune response, and a more pro-angiogenic and pro-fibrotic profile. MAT seems to have a significant role in the pathogenesis of CD.
PB Springer Nature
YR 2025
FD 2025-07-02
LK https://hdl.handle.net/10630/39635
UL https://hdl.handle.net/10630/39635
LA eng
NO Martín-Reyes, F., Kentaoui-Bousellam, I., Ruiz-Malagón, A. J., Ho-Plágaro, A., López-Gómez, C., Herraiz-Vilela, M., Alcaín-Martínez, G., Camargo-Camero, R., Martos-VanDussen, J. V., Camacho-Martel, L., Gutiérrrez-Martínez, F., Arranz-Salas, I., Ortega-Jimenez, M. V., Escamilla-Sánchez, A., Daza-González, J. J., Sanchiz-Cardenas, E., Rivas-Becerra, J., García-Fuentes, E., Rodríguez-Pacheco, F., & Rodriguez-Diaz, C. (2025). Mesenteric adipose tissue in Crohn's disease alters the immune response of the ileal mucosa and increases angiogenesis and fibrosis. Scientific reports, 15(1), 22591. https://doi.org/10.1038/s41598-025-07147-7
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 22 ene 2026