RT Journal Article
T1 Phase angle as a marker of outcome in hospitalized pediatric patients. A systematic review of the evidence (GRADE) with meta-analysis.
A1 Fernández-Jiménez, Rocío
A1 Martin‐Masot, Rafael
A1 Cornejo Pareja, Isabel María
A1 Vegas-Aguilar, Isabel M.
A1 Herrador-López, Marta
A1 Tinahones-Madueño, Francisco José
A1 Navas-López, Víctor Manuel
A1 Bellido-Guerrero, Diego
A1 García-Almeida, José Manuel
K1 Endocrinología pediátrica
AB Phase angle (PhA) is a valuable tool for evaluating the nutritional and inflammatory status, which can accompany acute and severe disorders. PhA is a cellular health biomarker, whose value is particularly substantial due to the negative consequences of these situations in the pediatric population. Relevant literature was collected with the aim of comprehensively analysing the evidence on the association between an altered PhA can serve as a predictive-marker for mortality and poor-outcomes in at-risk-pediatric patients. Understanding this relationship could have significant implications for identifying high-risk individuals and implementing timely interventions. A systematic review with meta-analysis was conducted in the primary electronic databases from inception until January 2023. Overall, four studies with a total of 740 patients were eligible for our analysis. Evidence demonstrates that PhA is associated with nutritional status, reflecting undernutrition and changes in body composition related to illness. This review suggests that PhA can indeed be used as an indicator of nutritional status and a tool for predicting prognosis, including mortality and poor-outcomes, in hospitalized pediatric patients. A low PhA was associated with a significant mortality risk [RR:1.51;95%CI (1.22–1.88),p = 0.0002;I2 = 0%,(p = 0.99)] and an increased complications risk [OR:8.17;95%CI (2.44–27.4),p = 0.0007;I2 = 44%,(p = 0.18)]. These findings highlight the importance of taking a comprehensive approach to clinical nutrition, integrating multiple evaluation aspects to establish an accurate diagnosis and personalized therapeutic plans. While PhA emerges as a valuable tool for assessing the risk of malnutrition and as a prognostic-indicator for poor-outcomes in pediatric patients. Further future studies are needed to focus on investigating this relationship in larger and diverse population to strengthen the evidence base.
PB Elsevier
YR 2023
FD 2023
LK https://hdl.handle.net/10630/33835
UL https://hdl.handle.net/10630/33835
LA eng
NO Fernández-Jiménez, R., Martín-Masot, R., Cornejo-Pareja, I. et al. Phase angle as a marker of outcome in hospitalized pediatric patients. A systematic review of the evidence (GRADE) with meta-analysis. Rev Endocr Metab Disord 24, 751–765 (2023). https://doi.org/10.1007/s11154-023-09817-1
NO Funding for open access publishing: Universidad Málaga/CBUA
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026