RT Journal Article
T1 Sex Differences in Plasma Lysophosphatidic Acid Species in Patients with Alcohol and Cocaine Use Disorders
A1 Flores-López, María
A1 García-Marchena, Nuria
A1 Araos Gómez, Pedro Fernando
A1 Requena-Ocaña, Nerea
A1 Porras-Perales, Oscar
A1 Torres-Galván, Sandra
A1 Suárez-Pérez, Juan
A1 Pizarro Lozano, Nieves
A1 De la Torre, Rafael
A1 Rubio, Gabriel
A1 Ruiz-Ruiz, Juan Jesús
A1 Rodriguez-de-Fonseca, Fernando
A1 Serrano, Antonia
A1 Pavón-Morón, Francisco Javier
K1 Drogas
AB Preclinical evidence suggests a main role of lysophosphatidic acid (LPA) signaling indrug addiction. Recently, we reported alterations in the plasma concentrations of LPA species inpatients with alcohol use disorder (AUD). As there are sex differences in drug addiction, the mainaim of the present study was to investigate whether relevant LPA species (16:0-LPA, 18:0-LPA, 18:1-LPA, 18:2-LPA and 20:4-LPA) were associated with sex and/or substance use disorder (SUD). Thisexploratory study was conducted in 214 abstinent patients with lifetime SUD, and 91 healthy controlsubjects. The SUD group was divided according to the diagnosis of AUD and/or cocaine use disorder(CUD). Participants were clinically assessed, and plasma samples were collected to determine LPAspecies and total LPA. We found that LPA concentrations were significantly affected by sex, andwomen showed higher concentrations than men. In addition, there were significantly lower 16:0-LPA,18:2-LPA and total LPA concentrations in patients with SUD than in controls. Namely, patients withCUD and AUD + CUD showed lower LPA concentrations than controls or patients with AUD. Inconclusion, our data suggest that LPA species could be potential biomarkers for SUD in women andmen, which could contribute to a better stratification of these patients in treatment programs.
PB IOAP-MPDI
YR 2022
FD 2022-04-30
LK https://hdl.handle.net/10630/24350
UL https://hdl.handle.net/10630/24350
LA eng
NO Flores-López M, García-Marchena N, Araos P, Requena-Ocaña N, Porras-Perales O, Torres-Galván S, Suarez J, Pizarro N, de la Torre R, Rubio G, Ruiz-Ruiz JJ, Rodríguez de Fonseca F, Serrano A, Pavón-Morón FJ. Sex Differences in Plasma Lysophosphatidic Acid Species in Patients with Alcohol and Cocaine Use Disorders. Brain Sciences. 2022; 12(5):588. https://doi.org/10.3390/brainsci12050588
NO This study has been supported by the following programs and research projects: Subprograma Redes Temáticas RETICS (Red de Trastornos Adictivos RD16/0017/0001) and Redes de investigación Cooperativas Orientadas al Resultado en Salud (RECORs RD21/0009/0003) funded by Instituto de Salud Carlos III (ISCIII), Ministerio de Ciencia e Innovación and the European Regional Development Funds/European Social Fund (ERDF/ESF); Proyectos de Investigación en Salud (PI19/00886,PI19/01577 and PI20/01399) funded by ISCIII and ERDF/ESF; Proyectos de Investigación en Drogodependencias (PND2017I043, PND2018I033, PNSD2018I044 and PND2019I040) funded by Delegacióndel Gobierno para el Plan Nacional sobre Drogas, Ministerio de Sanidad and ERDF/ESF; Proyectosde Investigación en Salud (PI-0140-2018) funded by Consejería de Salud y Familias, Junta de Andalucía and ERDF/ES; and Proyecto I + D + I en el marco del Programa Operativo FEDER Andalucía 2014–2020 (UMA18-FEDERJA-059) funded by Consejería de Economía, Conocimiento, Empresas y Universidad, Junta de Andalucía and ERDF/ES. M.F.-L. holds a “PFIS” Predoctoral research contract (FI18/00249), N.G.-M. holds a “Sara Borrell” research contract (CD19/00019), A.S. holds a MiguelServet II” research contract (CPII19/00031) and F.J.P.-M. holds a “Miguel Servet II” research contract (CPII19/00022) funded by ISCIII and ERDF/ESF. Partial funding for open access charge: Universidad de Málaga
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026