RT Journal Article
T1 Electrospraying as a Technique for the Controlled Synthesis of Biocompatible PLGA@Ag2S and PLGA@Ag2S@SPION Nanocarriers with Drug Release Capability
A1 Alvear-Jiménez, Alexis
A1 Zabala-Gutiérrez, Irene
A1 Shen, Yingli
A1 Villaverde, Gonzalo
A1 Lozano-Chamizo, Laura
A1 Guardia, Pablo
A1 Tinoco, Miguel
A1 Gacía-Pinel, Beatriz
A1 Prados, José
A1 Melguizo, Consolación
A1 López-Romero, Juan Manuel
A1 Jaque, Daniel
A1 Filice, Marco
A1 Contreras-Cáceres, Rafael
K1 Nanopartículas
K1 Oxidos de hierro
K1 Biocompatibilidad
AB Ag2S nanoparticles are near-infrared (NIR) probes providing emission in a specific spectralrange (~1200 nm), and superparamagnetic iron oxide nanoparticles (SPION) are colloidal systems ableto respond to an external magnetic field. A disadvantage of Ag2S NPs is the attenuated luminescentproperties are reduced in aqueous media and human fluids. Concerning SPION, the main drawback isthe generation of undesirable clusters that reduce particle stability. Here, we fabricate biocompatiblehybrid nanosystems combining Ag2S NPs and SPION by the electrospraying technique for drugdelivery purposes. These nanostructures are composed of poly(lactic-co-glycolic acid) (PLGA) asthe polymeric matrix in connection with both Ag2S NPs and SPIONs. Initially, we fabricate a hybridcolloidal nanosystem composed of Ag2S NPs in connection with PLGA (PLGA@Ag2S) by threedifferent routes, showing good photoluminescent (PL) properties with relatively high average decaytimes. Then, we incorporate SPIONs, obtaining a PLGA polymeric matrix containing both Ag2SNPs and SPION (PLGA@Ag2S@SPION). Interestingly, in this hybrid system, the location of Ag2SNPs and SPIONs depends on the synthesis route performed during electrospraying. After a detailedcharacterization, we demonstrate the encapsulation and release capabilities, obtaining the kineticrelease using a model chemotherapeutic drug (maslinic acid). Finally, we perform in vitro cytotoxicityassays using drug-loaded hybrid systems against several tumor cell lines.
PB MDPI
YR 2022
FD 2022
LK https://hdl.handle.net/10630/40455
UL https://hdl.handle.net/10630/40455
LA eng
NO Alvear-Jiménez, A.; Zabala Gutierrez, I.; Shen, Y.; Villaverde, G.; Lozano-Chamizo, L.; Guardia, P.; Tinoco, M.; Garcia-Pinel, B.; Prados, J.; Melguizo, C.; et al. Electrospraying as a Technique for the Controlled Synthesis of Biocompatible PLGA@Ag2S and PLGA@Ag2S@SPION Nanocarriers with Drug Release Capability. Pharmaceutics 2022, 14, 214. https://doi.org/10.3390/pharmaceutics14010214
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026