RT Journal Article
T1 Unexpectedly large number of conserved noncoding regions within the ancestral chordate Hox cluster
A1 Pascual-Anaya, Juan
A1 D'Aniello, Salvatore
A1 Garcia-Fernàndez, Jordi
K1 Genética evolutiva
AB The single amphioxus Hox cluster contains 15 genes and may well resemble the ancestral chordate Hox cluster. We have sequenced the Hox genomic complement of the European amphioxus Branchiostoma lanceolatum and compared it to the American species, Branchiostoma floridae, by phylogenetic footprinting to gain insights into the evolution of Hox gene regulation in chordates. We found that Hox intergenic regions are largely conserved between the two amphioxus species, especially in the case of genes located at the 3′ of the cluster, a trend previously observed in vertebrates. We further compared the amphioxus Hox cluster with the human HoxA, HoxB, HoxC, and HoxD clusters, finding several conserved noncoding regions, both in intergenic and intronic regions. This suggests that the regulation of Hox genes is highly conserved across chordates, consistent with the similar Hox expression patterns in vertebrates and amphioxus.
PB Springer
YR 2008
FD 2008
LK https://hdl.handle.net/10630/33153
UL https://hdl.handle.net/10630/33153
LA eng
NO Pascual-Anaya, J., D’Aniello, S. & Garcia-Fernàndez, J. Unexpectedly large number of conserved noncoding regions within the ancestral chordate Hox cluster. Dev Genes Evol 218, 591–597 (2008). https://doi.org/10.1007/s00427-008-0246-8
NO This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s00427-008-0246-8
NO Ministerio de Educación y Ciencia, proyecto BFU2005-00252
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026