RT Conference Proceedings
T1 A network biology approach to novel therapeutic estrategies
T2 Nuevas estrategias terapéuticas basadas en biología de redes
A1 Aloy, Patrick
K1 Antropología médica
AB Network and systems biology offer a novel way of approaching drug discovery by developing models that consider the global physiological environment of protein targets, and the effects of modifying them, without losing the key molecular details. Here we review some recent advances in network and systems biology applied to human health, and discus how they can have a big impact on some of the most interesting areas of drug discovery. In particular, we claim that network biology will play a central part in the development of novel polypharmacology strategies to fight complex multifactorial diseases, where efficacious therapies will need to center on altering entire pathways rather than single proteins. We briefly present new developments in the two areas where we believe network and system biology strategies are more likely to have an immediate contribution: combinatorial therapies in cancer and drug repurposing.
YR 2017
FD 2017-05-30
LK http://hdl.handle.net/10630/13772
UL http://hdl.handle.net/10630/13772
LA spa
NO Conferenciante invitado al ciclo de conferencias del Máster en Biología Celular y Molecular
NO Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 26 ene 2026