RT Journal Article
T1 Effect on nutritional status and biomarkers of inflammation and oxidation of an oral nutritional supplement (with or without probiotics) in malnourished hemodialysis patients. A multicenter randomized clinical trial "Renacare Trial"
A1 Hevilla, Francisco
A1 Padial, Marina
A1 Blanca, María
A1 Barril, Guillermina
A1 Jiménez-Salcedo, Tamara
A1 Ramírez-Ortiz, Mercedes
A1 Nogueira, Ángel
A1 Gentile, Adriana Mariel
A1 García-Escobar, Eva
A1 Romero-Zerbo, Silvana Yanina
A1 Olveira-Fuster, Gabriel María
K1 Hemodializados - Nutrición
K1 Marcadores bioquímicos
AB Background: Malnutrition in patients undergoing hemodialysis is frequent and associated with a reduction in muscular mass and strength, with an increment in biomarkers of inflammation and oxidation. Materials and methods: Randomized, multicenter, parallel-group trial in malnourished hemodialysis patients with three groups [(1) control (C) individualized diet, (2) oral nutritional supplement-ONS- + placebo-SU- PL-, and (3) ONS + probiotics-SU-PR]; the trial was open regarding the intake of ONS or individualized diet recommendations, but double-blind for the intake of probiotics. We obtained, at baseline and after 3 and 6 months, anthropometric measurements, handgrip strength, bioelectrical impedance analysis (BIA), dietary records, and routine biochemical parameters. Inflammation and oxidation were determined using ELISA techniques (Versamax and ProcartaPlex multiplex Immunoassay). Results were analyzed by intention to treat. Results: A total of 31 patients (11 corresponding to group C, 10 to SU-PL, and 10 to SU-PR) completed the 6-months trial. The two groups that took supplements significantly increased their protein calorie, fat (total and n-3), and fiber intake. Weight and fat-free mass (FFM) also increased significantly in the groups on supplements, both at 3 and 6 months, and dynamometry did so in the SU-PL group. At month 3, prealbumin and vitamin D were significantly increased in the SU-TOT (SU-PL + SU-PR) group. No changes were observed regarding levels of phosphorus and potassium in any of the groups. Urea increased significantly at 6 months in the SU-PL group. There were significant changes in some inflammation biomarkers in the groups on supplements during the intervention (brain-derived neurotrophic factor, bone morphogenetic protein-2, MCP-1, IL-1-beta, IL-10, IL-4, and IL-8). The total antioxidant capacity (TAC) increased significantly in the supplemented patients, with no significant changes observed in isoprostanes.
PB Frontiers Media
YR 2023
FD 2023
LK https://hdl.handle.net/10630/39358
UL https://hdl.handle.net/10630/39358
LA eng
NO Front Nutr. 2023 Feb 3;10:1107869
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026