RT Journal Article
T1 Early neuropathology of somatostatin/NPY GABAergic cells in the hippocampus of a PS1xAPP transgenic model of Alzheimer's disease.
A1 Ramos, Blanca
A1 Baglietto-Vargas, David
A1 del Rio, Juan Carlos
A1 Moreno-González, Inés
A1 Santa-Maria, Consuelo
A1 Jiménez, Sebastián
A1 Caballero, Cristina
A1 López-Téllez, Juan Félix
A1 Khan, Zafar U.
A1 Ruano, Diego
A1 Gutiérrez-Pérez, Antonia
A1 Vitorica Ferrández, Javier
K1 Alzheimer, Enfermedad de
AB At advanced stages, Alzheimer's disease (AD) is characterized by an extensive neuronal loss. However, the early neurodegenerative deficiencies have not been yet identified. Here we report an extensive, selective and early neurodegeneration of the dendritic inhibitory interneurons (oriens-lacunosum moleculare, O-LM, and hilar perforant path-associated, HIPP, cells) in the hippocampus of a transgenic PS1 × APP AD model. At 6 months of age, from 22 different pre- and postsynaptic mRNA markers tested (including GABAergic, glutamatergic and cholinergic markers), only the expression of somatostatin (SOM) and NPY neuropeptides (O-LM and HIPP markers) displayed a significant decrease. Stereological cell counting demonstrated a profound diminution (50–60%) of SOM-immunopositive neurons, preceding the pyramidal cell loss in this AD model. SOM population co-expressing NPY was the most damaged cell subset. Furthermore, a linear correlation between SOM and/or NPY deficiency and Abeta content was also observed. Though the molecular mechanism of SOM neuronal loss remains to be determined, these findings might represent an early hippocampal neuropathology. Therefore, SOM and NPY neuropeptides could constitute important biomarkers to assess the efficacy of potential early AD treatments.
PB Elsevier
YR 2006
FD 2006-11
LK https://hdl.handle.net/10630/36524
UL https://hdl.handle.net/10630/36524
LA eng
NO Ramos B, Baglietto-Vargas D, del Rio JC, Moreno-Gonzalez I, Santa-Maria C, Jimenez S, Caballero C, Lopez-Tellez JF, Khan ZU, Ruano D, Gutierrez A, Vitorica J. Early neuropathology of somatostatin/NPY GABAergic cells in the hippocampus of a PS1xAPP transgenic model of Alzheimer's disease. Neurobiol Aging. 2006 Nov;27(11):1658-72. doi: 10.1016/j.neurobiolaging.2005.09.022. Epub 2005 Nov 3. PMID: 16271420.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026