RT Journal Article
T1 Dietary Fatty Acids Sustain the Growth of the Human Gut Microbiota
A1 Agans, Richard
A1 Gordon, Alex
A1 Kramer, Denise Lynette
A1 Pérez-Burillo, Sergio
A1 Rufián-Henares, José Ángel
A1 Paliy, Oleg
K1 Nutrición
AB While a substantial amount of dietary fats escape absorption in the human small intestine and reach the colon, the ability of resident microbiota to utilize these dietary fats for growth has not been investigated in detail. In this study, weused an in vitro multivessel simulator system of the human colon to reveal that the human gut microbiota is able to utilize typically consumed dietary fatty acids to sustain growth. Gut microbiota adapted quickly to a macronutrient switch from a balancedWestern diet-type medium to its variant lacking carbohydrates and proteins. We defined specific genera that increased in their abundances on the fats-only medium, including Alistipes, Bilophila, and several genera of the class Gammaproteobacteria.In contrast, the abundances of well-known glycan and protein degraders, including Bacteroides, Clostridium, and Roseburia spp., were reduced under such conditions. The predicted prevalences of microbial genes coding for fatty acid degradationenzymes and anaerobic respiratory reductases were significantly increased in the fats-only environment, whereas the abundance of glycan degradation genes was diminished. These changes also resulted in lower microbial production of shortchainfatty acids and antioxidants. Our findings provide justification for the previously observed alterations in gut microbiota observed in human and animal studies of high-fat diets.
PB American Society for Microbiology
YR 2018
FD 2018
LK https://hdl.handle.net/10630/32350
UL https://hdl.handle.net/10630/32350
LA eng
NO Agans R, Gordon A, Kramer DL, Perez- Burillo S, Rufián-Henares JA, Paliy O. 2018. Dietary fatty acids sustain the growth of the human gut microbiota. Appl Environ Microbiol 84:e01525-18. https://doi.org/10.1128/AEM .01525-18.
NO Parts of this work were supported by Dayton Area Graduate Studies Institute award RH15-WSU-15-1 to R.A., A.G., and O.P., by National Science Foundation award DBI- 1335772 to O.P., and by award AGL2014-53895-R from the Spanish Ministry of Economyand Competitiveness and by the European Regional Development Fund (FEDER) to S.P.-B. and J.A.R.-H.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026