RT Journal Article
T1 Neuroprotective Effect of 3′,4′-Dihydroxyphenylglycol in Type-1-like Diabetic Rats—Influence of the Hydroxytyrosol/3′,4′-dihydroxyphenylglycol Ratio
A1 Rodríguez-Pérez, María Dolores
A1 Pérez de Algaba Fuentes, Inmaculada
A1 Martín Aurioles, Esther
A1 Ortega-Hombrados, Laura
A1 Verdugo, Cristina
A1 Fernández-Prior, María África
A1 Bermúdez-Oria, Alejandra
A1 De-la-Cruz-Cortés, José Pedro
A1 González-Correa, José Antonio
K1 Diabetes
AB The aim of this study was to assess the possible neuroprotective effect of 3′,4′-dihydroxyphenylglycol (DHPG), a polyphenol from extra virgin olive oil (EVOO), in an experimental model of diabetes and whether this effect is modified by the presence of another EVOO polyphenol, hydroxytyrosol (HT). The neuroprotective effect was assessed in a hypoxia–reoxygenation model in brain slices and by quantifying retinal nerve cells. The animals were distributed as follows: (1) normoglycemic rats (NDR), (2) diabetic rats (DR), (3) DR treated with HT (5 mg/kg/day p.o.), (4) DR treated with DHPG (0.5 mg/kg/day), or (5) with 1 mg/kg/day, (6) DR treated with HT plus DHPG 0.5 mg/kg/day, or (7) HT plus 1 mg/kg/day p.o. DHPG. Diabetic animals presented higher levels of oxidative stress variables and lower numbers of neuronal cells in retinal tissue. The administration of DHPG or HT reduced most of the oxidative stress variables and brain lactate dehydrogenase efflux (LDH) as an indirect index of cellular death and also reduced the loss of retinal cells. The association of DHPG+HT in the same proportions, as found in EVOO, improved the neuroprotective and antioxidant effects of both polyphenols.
PB IOAP-MPDI
YR 2022
FD 2022-03-08
LK https://hdl.handle.net/10630/24140
UL https://hdl.handle.net/10630/24140
LA eng
NO Rodríguez-Pérez MD, Pérez de Algaba I, Martín-Aurioles E, Arrebola MM, Ortega-Hombrados L, Verdugo C, Fernández-Prior MÁ, Bermúdez-Oria A, De La Cruz JP, González-Correa JA. Neuroprotective Effect of 3′,4′-Dihydroxyphenylglycol in Type-1-like Diabetic Rats—Influence of the Hydroxytyrosol/3′,4′-dihydroxyphenylglycol Ratio. Nutrients. 2022; 14(6):1146. https://doi.org/10.3390/nu14061146
NO This study was supported, in part, by the Consejería de Salud. Junta de Andalucía (Spain), Proyectos de Investigación en Salud [Regional Ministry of Health. Junta de Andalucía (Spain), Health Research Projects] (PI-0129-2017). Partial funding for open access charge: Universidad de Málaga.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026