RT Journal Article
T1 Progress and hurdles of therapeutic nanosystems against cancer
A1 Martín Contreras, Marina
A1 Navarro-Marchal, Saúl
A1 Peula-García, José Manuel
A1 Jódar-Reyes, Ana Belén
K1 Nanopartículas
AB Nanomedicine against cancer, including diagnosis, prevention and treatment, has increased expectations for the solution of many biomedical challenges in the fight against this disease. In recent decades, an exhaustive design of nanosystems with high specificity, sensitivity and selectivity has been achieved due to a rigorous control over their physicochemical properties and an understanding of the nano–bio interface. However, despite the considerable progress that has been reached in this field, there are still different hurdles that limit the clinical application of these nanosystems, which, along with their possible solutions, have been reviewed in this work. Specifically, physiological processes as biological barriers and protein corona formation related to the administration routes, designing strategies to overcome these obstacles, promising new multifunctional nanotherapeutics, and recent clinical trials are presented in this review.
PB MDPI
YR 2022
FD 2022-02
LK https://hdl.handle.net/10630/28849
UL https://hdl.handle.net/10630/28849
LA spa
NO Martín-Contreras, M.; Navarro-Marchal, S.A.; Peula-García, J.M.; Jódar-Reyes, A.B. Progress and Hurdles of Therapeutic Nanosystems against Cancer. Pharmaceutics 2022, 14, 388. https://doi.org/10.3390/pharmaceutics14020388
NO This research was funded by FEDER/Junta de Andalucía-Consejería de Transformación Económica, Industria, Conocimiento y Universidades, Projects (PY20_00241 and A-FQM-90-UGR20).
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026