RT Conference Proceedings
T1 Study of the antitumor potential of stauprimide in breast cancer
A1 Carrillo Fernández, Paloma
A1 Téllez Quijorna, Clara
A1 Bernal, Manuel
A1 Rodríguez-Quesada, Ana María
A1 Medina-Torres, Miguel Ángel
A1 Martínez-Póveda, Beatriz Amparo
K1 Cáncer - Congresos
AB Stauprimide, a semi-synthetic derivative of staurosporine, was characterized in 2009 as a potent differentiation-enhancing compound in embryonic stem cells [1]. Although it was first thought that this compound could maintain the properties of staurosporine as a non-selective inhibitor of protein kinases (especially potent in inhibiting tyrosine kinases), it was found that its potential as an inhibitor of these proteins was not particularly remarkable, ruling out this as its main mechanism of action for the differentiation-enhancing effect. However, a clear effect of stauprimide on embryonic stem cells was identified as an inhibitor of CMYC expression, a key factor in the maintenance of stem cell pluripotency [1]. Given the involvement of CMYC in cancer development, and the effect of stauprimide inhibiting its expression, this compound was proposed as a possible antitumor drug in the treatment of renal cancer [2].In this work we have studied the in vitro antitumor effect of stauprimide in the context of breast cancer, exploring also the possible mechanisms of action by which stauprimide exerts its effects. The detected activity of this compound on the human adenocarcinoma model used in our studies suggests its potential usefulness in antitumor pharmacological strategies.
YR 2021
FD 2021
LK https://hdl.handle.net/10630/22854
UL https://hdl.handle.net/10630/22854
LA eng
NO Contribución a Congreso (póster)
NO Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech. Este trabajo está financiado por fondos de los proyectos PID2019-105010RB-100 (Ministerio de Ciencia, Gobierno de España), UMA18-FEDERJA-220 (Junta de Andalucía y fondos FEDER), Ayudas a Proyectos de Investigación en Salud del Plan Propio de IBIMA 2020 y fondos del grupo BIO-267 (Junta de Andalucía).
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026