RT Journal Article
T1 Serum copper levels and risk of major adverse cardiovascular events: a systematic review and meta-analysis
A1 Muñoz-Bravo, Carlos
A1 Soler-Iborte, Eva
A1 Lozano-Lorca, Macarena
A1 Kouiti, Malak
A1 González-Palacios Torres, Carla
A1 Barrios-Rodríguez, Rocío
A1 Jiménez-Moleón, José Juan
K1 Enfermedad cerebrovascular
K1 Suero
K1 Cobre
AB Background: Despite the fact that several studies have investigated the association between serum copper levels (S-Cu) and the risk of cardiovascular diseases, this relationship remains unclear. The aims of this study were to investigate the association between S-Cu and risk of major adverse cardiovascular events (MACE), including total stroke, ischemic stroke, hemorrhagic stroke, myocardial infarction and cardiovascular mortality, and identify potential sources of results heterogeneity.Methods: We carried out a systematic review and meta-analysis. The selection criteria were: (1) Observational studies (cohort studies, case-control studies and hybrid studies); (2) Studies containing quantitative data about the relationshipbetween S-Cu and risk of MACE; (3) Estimating association measures; and (4) Studies written in English, French or Spanish. Overall pooled Odds ratio    (pOR) and 95% confidence intervals (95% CI) of MACE for the highest vs. lowestS-Cu category were calculated using random-effects models.Results: Sixteen studies with a total of 41,322 participants were included in the meta-analysis: 10 prospective cohort studies, 5 nested case-control studies and 1 case-control study. Comparing highest vs. lowest category, high S-Cu levels wereassociated with total stroke (pOR: 1.49, 95% CI 1.22–1.82; I2=0%, p=0.54), myocardial infarction (pOR: 1.31, 95% CI 1.17–1.46; I2=0.0%, p=0.92) and cardiovascular mortality (pOR: 1.60, 95% CI 1.39–1.86; I2=0.0%, p=0.54). Subgroup analysis showed that studies with a hybrid design had higher risks for cardiovascular mortality (pOR: 3.42, 95% CI 1.98–5.92) and ischemic stroke (pOR: 1.54, 95% CI 1.30–1.83).Conclusion: High S-Cu levels were associated with an increased risk of total stroke, myocardial infarction and cardiovascular mortality. Hybrid studies seems to modify the strength of the association between S-Cu and the risk of cardiovascular mortality and ischemic stroke.
PB Frontiers Media
YR 2023
FD 2023
LK https://hdl.handle.net/10630/34491
UL https://hdl.handle.net/10630/34491
LA eng
NO Muñoz-Bravo C, Soler-Iborte E, LozanoLorca M, Kouiti M, González-Palacios Torres C, Barrios-Rodríguez R and Jiménez-Moleón JJ (2023) Serum copper levels and risk of major adverse cardiovascular events: a systematic review and meta-analysis. Front. Cardiovasc. Med. 10:1217748. doi: 10.3389/fcvm.2023.1217748
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026