RT Journal Article
T1 Indolenine-Based Derivatives as Customizable Two-Photon Fluorescent Probes for pH Bioimaging in Living Cells
A1 Benítez-Martín, Carlos
A1 Guadix-Domínguez, Juan Antonio
A1 Pearson, John
A1 Nájera-Albendín, Francisco
A1 Pérez-Pomares, José María
A1 Perez-Inestrosa, Ezequiel
K1 Detectores de fotones
AB Novel pH probes based on 2-(6-methoxynaphthalen-2-yl)-3,3-dimethyl3H-indole have been synthesized and characterized. These compounds display excellent“off−on” fluorescence responses to acidic pH especially under two-photon (TP) excitationconditions as well as strong selectivity and sensitivity toward H+. These features aresupported by fluorescence quantum yields over 35%, TP cross sections ∼60 GM, andgood resistance to photodegradation under acidic conditions. The synthetic versatility ofthis model allows subcellular targets to be tuned through minor scaffold modificationswithout affecting its optical characteristics. The effectiveness of the probes’ innatephotophysical properties and the structural modifications for different pH-relatedapplications are demonstrated in mouse embryonic fibroblast cells
PB American Chemical Society
YR 2020
FD 2020
LK https://hdl.handle.net/10630/36322
UL https://hdl.handle.net/10630/36322
LA eng
NO Carlos Benitez-Martin, Juan A. Guadix, John R. Pearson, Francisco Najera, Jose M. Perez-Pomares, and Ezequiel Perez-Inestrosa ACS Sensors 2020 5 (4), 1068-1074 DOI: 10.1021/acssensors.9b02590
NO Spanish Ministerio de Ciencia, Innovación y UniversidadesConsejería de Salud, Junta de AndalucíaUniversidad de Málaga-Junta de AndalucíaFEDER funds
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026