RT Journal Article
T1 Interferon receptor expression in multiple sclerosis patients
A1 Oliver-Martos, Begoña
A1 Mayorga Mayorga, Cristobalina
A1 Leyva-Fernández, Laura
A1 León, Antonio
A1 Luque, Gloria
A1 C Lopez, Juan
A1 Tamayo, Jose A
A1 Pinto-Medel, Maria Jesús
A1 De Ramón, Enrique
A1 Blanco, Eva
A1 Alonso, Ana
A1 Fernández Fernández, Óscar
K1 Esclerosis múltiple
AB To determine the gene expression of IFNAR1, IFNAR2 and MxA protein and the association with IFNbeta treatment response in MS patients. MS patients treated with IFNbeta had a significant decrease in IFNAR1 and IFNAR2 expression, and a significant increase in MxA compared to non-treated patients and healthy controls. Also, those patients who had a good response to treatment had a significant decrease in IFNAR1 and IFNAR2 expression compared to non-responders, non-treated patients and healthy controls. IFNbeta influences the expression of its receptors, and is greater in patients who respond to IFNbeta treatment. This down-regulation could be indicative of the response to IFNbeta.
PB Elsevier
YR 2006
FD 2006
LK https://hdl.handle.net/10630/33967
UL https://hdl.handle.net/10630/33967
LA eng
NO Oliver B, Mayorga C, Fernández V, Leyva L, León A, Luque G, López JC, Tamayo JA, Pinto-Medel MJ, de Ramon E, Blanco E, Alonso A, Fernández O. Interferon receptor expression in multiple sclerosis patients. J Neuroimmunol. 2007 Feb;183(1-2):225-31. doi: 10.1016/j.jneuroim.2006.11.010. Epub 2006 Dec 26. PMID: 17188754.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026