RT Journal Article
T1 Adult hippocampal neurogenesis as a target for cocaine addiction: a review of recent developments
A1 Castilla-Ortega, María Estela
A1 Santín-Núñez, Luis Javier
K1 Toxicomanía
K1 Neurobiología del desarrollo
K1 Hipocampo (Cerebro)
AB Basic research in rodents has shown that adult hippocampal neurogenesis (AHN) plays a key role in neuropsychiatric disorders that compromise hippocampal functioning. The discovery that dependence-inducing drugs regulate AHN has led to escalating interest in the potential involvement of AHN in drug addiction over the last decade, with cocaine being one of the most frequently investigated drugs. This review argues that, unlike other drugs of abuse, preclinical evidence does not, overall, support that cocaine induces a marked or persistent impairment in AHN. Nevertheless, experimental reduction of AHN consistently exacerbates vulnerability to cocaine. Interestingly, preliminary evidence suggests that, on the contrary, increasing AHN might help both to prevent and treat addiction.
PB Elsevier
YR 2020
FD 2020
LK https://hdl.handle.net/10630/23837
UL https://hdl.handle.net/10630/23837
LA eng
NO Castilla-Ortega, E., & Santín, L. J. (2020). Adult hippocampal neurogenesis as a target for cocaine addiction: a review of recent developments. Current Opinion in Pharmacology, 50, 109–116. https://doi.org/10.1016/J.COPH.2019.10.002
NO Author manuscript
NO This study was funded by grants from the Spanish Ministry of Economy and Competitiveness (MINECO, Agencia Estatal de Investigación) cofounded by the European Regional Development Fund -AEI/FEDER, UE- (‘Jóvenes Investigadores grant’ PSI2015-73156-JIN to E.C.O.; and PSI2017-82604R to L.J.S.).
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026