RT Conference Proceedings
T1 New Approaches in the Manufacture of Biomaterials for Betalactam Allergic Diagnose
A1 Collado-Martín, Daniel
A1 Pérez-de-Inestrosa-Villatoro, Ezequiel
A1 Ruiz-Sanchez, Antonio Jesus
A1 Mayorga Mayorga, Cristobalina
A1 Torres-Jaén, María Josefa
K1 Alergia a los medicamentos
AB Betalactams are the most widely utilized drugs against infections but are the primary cause of allergic reactions toantibiotic drugs. REF1 An accurate diagnosis of these allergic reactions to betalactams is crucial to avoid the use ofunnecessary alternative antibiotics that may reduce efficacy, lead to prolonged treatments, have a higher toxicity or inducebacterial resistance. The most consensual approach to diagnose betalactam allergy are in vivo tests. However, they are notrisky free, require experienced personnel and are both time-consuming and expensive for health-care systems, being so invitro test more appropriate or complementary to the in vivo tests. In vitro tests are not still widely used on account of theirlow sensitivity. Current efforts are in progress to improve these assays, thus allowing for better diagnosis of allergic responseswithin patients. REF 2We report progress in the preparation of new functional materials for in vitro allergic diagnosis testing. In particular,the application of new approaches employing orthogonally functionalised fluorescent dyes based upon 4-amino-1,8naphthalimide joined with the multivalence of polyamide dendrimers. REF 3 The in vitro diagnosis capabilities of thesefunctional materials was verified by testing on patient sera samples, with results demonstrating their potential for applicationwithin the healthcare industry.Acknowledgments: The present study has been supported by MINECO CTQ2016-75870P; by Andalusian RegionalMinistry Health (grants: PI-0250-2016); by the European Regional Development Fund (ERDF) and “Plan PropioUniversidad de Málaga” (UMA-Andalucía-TECH).
YR 2019
FD 2019-09-11
LK https://hdl.handle.net/10630/18321
UL https://hdl.handle.net/10630/18321
LA eng
NO Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026