RT Journal Article
T1 A lower duodenal immune response is associated with an increase of insulin resistance in patients with morbid obesity
A1 Ho-Plágaro, Ailec
A1 Saltiago-Fernández, Concepción
A1 García Serrano, Sara
A1 Rodríguez, Cristina
A1 Garrido-Sánchez, Lourdes
A1 Escamilla-Sánchez, Alejandro
A1 Gonzalo, Montserrat
A1 Montiel Casado, Custodia
A1 Alcaín-Martínez, Guillermo
A1 García-Muñoz, Beatriz
A1 Ruiz-Santana, Natalia
A1 Vázquez Pedreño, Luis
A1 García-Fuentes, Eduardo
K1 Histología
K1 Obesidad
AB The intestinal immune response could play an important role in obesity-related comorbidities. We aim to study the profile of duodenal cytokines and chemokines in patients with morbid obesity (MO), its relation with insulin resistance (IR) and the intake of metformin, and with the evolution of MO after sleeve gastrectomy (SG). In our work there is an association between a higher IR and a lower duodenal immune response in MO, with a slight increase in those patients with metformin treatment. Intestinal immune response could be involved in the evolution of BMI after SG.
PB Springer Nature
YR 2019
FD 2019-09-25
LK https://hdl.handle.net/10630/36157
UL https://hdl.handle.net/10630/36157
LA eng
NO Ho-Plagaro, A., Santiago-Fernandez, C., García-Serrano, S., Rodriguez, C., Garrido-Sanchez, L., Escamilla, A., Gonzalo, M., Montiel-Casado, C., Alcaín-Martínez, G., Garcia-Muñoz, B., Ruiz-Santana, N., Vázquez-Pedreño, L., & Garcia-Fuentes, E. (2020). A lower duodenal immune response is associated with an increase of insulin resistance in patients with morbid obesity. International journal of obesity (2005), 44(2), 340–352. https://doi.org/10.1038/s41366-019-0458-1
NO CIBER Fisiopatología de la Obesidad y Nutrición(CIBEROBN) and CIBER de Diabetes y Enfermedades Metabólicas(CIBERDEM) are initiatives of ISCIII (Spain). We gratefullyacknowledge the Imaging platform of the Institute of BiomedicalResearch in Malaga (IBIMA) (Spain). This work was supported in partby a grant from the Instituto de Salud Carlos III, Spain (PI12/00338)(“Una manera de hacer Europa”). This study has been co-funded byFEDER funds. AHP is supported by a grant from the Ministerio deEducación y Formación Professional (Spain) (FPU14/01972). CSF issupported by a grant from the ISCIII (Spain) (FI16/00241). LGS issupported by the Miguel Servet program from the ISCIII (Spain)(MS13/00188). CR is supported by a grant from BEIPD-COFUNDOPD,(Belgium) (R.EURO.0992-J-F-B-32). EGF is supported by theNicolas Monardes program from the Consejería de Salud de Andalucía(Spain) (C-0031-2016).
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 21 ene 2026