RT Conference Proceedings
T1 Evaluation of metabolism and biosignaling in the angiogenic microenvironment as potential targets for therapeutic intervention
A1 Medina-Torres, Miguel Ángel
A1 Ocaña Farfán, María del Carmen
A1 Martínez-Póveda, Beatriz Amparo
A1 Carrillo Fernández, Paloma
A1 Urdiales-Ruiz, José Luis
A1 Serrano, José J.
A1 Montañez, Raúl
A1 Rodríguez-Quesada, Ana María
K1 Cáncer
AB The "re-discovery" of Warburg effect at the turn of the present millennium has been a key determinant of the current renewed interest on cancer metabolism. In fact, metabolic reprogramming has been identified as one of the hallmarks of cancer. However, cancers grow in tight contact with non-tumoral accompanying cells and the surrounding extracellular matrix, as underlined by the concept of tumor microenvironment. Endothelial cells are key components of this tumor microenvironment, since they are requested for angiogenesis, another hallmark of cancer. In this complex system, rewiring of metabolism and signaling pathway in cancer, endothelial and other accompanying cell emerges as new potential targets for therapeutic intervention. In this communication, we will present the drug discovery and characterization approach of our group and our more recent results in this field, including new modeling with an evolutionary and ecological point of view.
YR 2017
FD 2017-08-29
LK http://hdl.handle.net/10630/14404
UL http://hdl.handle.net/10630/14404
LA eng
NO [Our experimental work is supported by grants BIO2014-56092-R (MINECO and FEDER) and P12-CTS-1507 (Andalusian Government and FEDER) and funds from group BIO-267 (Andalusian Government). The "CIBER de Enfermedades Raras" is an initiative from the ISCIII (Spain)]. This communication has the support of a travel grant "Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech".
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026