RT Conference Proceedings
T1 Synthesis of fluorescent dendrimeric antigen efficiently internalized by human dendritic cells
A1 Mesa-Antunez, Pablo
A1 Collado-Martín, Daniel
A1 Vida-Pol, Yolanda
A1 Nájera-Albendín, Francisco
A1 Fernández-Duarte, Tahía Diana
A1 Torres-Jaén, María Josefa
A1 Pérez-de-Inestrosa-Villatoro, Ezequiel
K1 Biomoléculas
K1 Biopolímeros
AB A new fluorescent dendrimeric antigen (DeAn) based on a dendron with amoxicilloyl terminal groups has been synthetized. The synthesis implies a novel class of all-aliphatic polyamide dendrimer (BisAminoalkylPolyAmide Dendrimers, or BAPAD).[1] The introduction of a cystamine core allows the incorporation of this dendrons into a 1,8-naphthalimide fluorofore functionalized with a maleimide group. The fluorescence properties of this DeAn has been studied and compared with the properties of an equivalent dendron possessing amino-terminal groups. This DeAn has been used as a synthetic antigen in a biomedical assay that tests the amoxicillin sensitivity of dendritic cells (DC) from tolerant and allergic patients.
PB Servicio de Publicaciones de la Universidad de Huelva
YR 2016
FD 2016
LK http://hdl.handle.net/10630/11676
UL http://hdl.handle.net/10630/11676
LA spa
NO Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 26 ene 2026