RT Journal Article
T1 Lycopene intake and prostate cancer risk in men at high cardiovascular risk: a prospective cohort study
A1 López‑Solís, Ricardo
A1 Castro‑Barquero, Sara
A1 Donat‑Vargas, Carolina
A1 Corrado, Marina
A1 Arancibia‑Riveros, Camila
A1 Martínez González, Miguel Ángel
A1 Salas-Salvadó, Jordi
A1 Sorlí, José V.
A1 Serra‑Majem, Luis
A1 Fitó, Montserrat
A1 Pintó, Xavier
A1 Fiol, Miquel
A1 Lapetra, José
A1 Gómez-Gracia, Enrique
A1 Toledo, Estefanía
A1 Ramírez‑Sabio, Judith B.
A1 Babio, Nancy
A1 Estruch, Ramón
A1 Ros, Emilio
A1 Lamuela-Raventós, Rosa M.
K1 Próstata - Cáncer - Prevención
AB Intake of lycopene has been proposed as a protective dietary factor against prostate cancer development. Cardiovascular disease and prostate cancer share risk factors, which may modulate the effect of lycopene in high-risk individuals. This study aimed to examine the association between lycopene intake and prostate cancer risk in a Mediterranean population at high cardiovascular risk.A prospective cohort analysis was conducted among 2970 men aged 55-80 years at high cardiovascular risk from the PREDIMED trial, a multicenter study in Spain. Lycopene intake was assessed using repeated food frequency questionnaires. Prostate cancer cases were identified through medical records and death certificates. Cox proportional hazard models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) across lycopene intake quartiles.Over a mean follow-up of 5.8 years, 104 prostate cancer cases were identified. Participants in the highest quartile of lycopene intake had a significantly lower risk of prostate cancer than those in the lowest quartile (HR: 0.46; 95% CI: 0.23-0.95; p-trend = 0.035). A nonlinear dose-response relationship was observed, with a significant inverse association emerging at intakes above 4.9 mg/day (HR: 0.36; 95% CI: 0.13-0.98).Higher lycopene intake suggested a protective association with a lower incidence of prostate cancer in men at high cardiovascular risk. These findings support the role of lycopene-rich diets in prostate cancer prevention, which may be particularly relevant for high cardiovascular risk populations.
PB Springer Nature
YR 2025
FD 2025-11
LK https://hdl.handle.net/10630/44735
UL https://hdl.handle.net/10630/44735
LA eng
NO López-Solís R, Castro-Barquero S, Donat-Vargas C, Corrado M, Arancibia-Riveros C, Martínez-González MÁ, Salas-Salvadó J, Sorlí JV, Serra-Majem L, Fitó M, Pintó X, Fiol M, Lapetra J, Gómez-Gracia E, Toledo E, Ramírez-Sabio JB, Babio N, Estruch R, Ros E, Lamuela-Raventós RM. Lycopene intake and prostate cancer risk in men at high cardiovascular risk: a prospective cohort study. BMC Med. 2025 Nov 10;23(1):627. doi: 10.1186/s12916-025-04440-0. PMID: 41214650; PMCID: PMC12604356.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 4 mar 2026