RT Conference Proceedings
T1 Cognitive impairment and persistent changes in exploration and hyperactivity in mice after withdrawn from chronic cocaine
A1 Mañas-Padilla, María del Carmen
A1 Ávila-Gámiz, Fabiola
A1 Gil Rodríguez, Sara
A1 Ladrón de Guevara-Miranda, David
A1 Rodriguez-de-Fonseca, Fernando
A1 Santín-Núñez, Luis Javier
A1 Castilla-Ortega, María Estela
K1 Conducta
AB Lasting neurobehavioral adaptations such as cognitive decline are induced by chronic cocaineexposure in animal models. However, persistent changes in motor and exploratory responses arerarely reported. In this study, mice were administered a cocaine dose (COC, 20 mg/kg/day) or saline(SAL) repeatedly for 12 consecutive days in their home cage. After 24 days of drug withdrawal, theywere submitted to a behavioral test battery to assess motor/exploratory activity and anxiety-likebehavior (elevated plus maze and open field tests), behavioral despair (forced swimming test),working and reference memory (spontaneous alternation behavior –SAB- and novel placerecognition memory tests). This behavioral assessment was carried out in drug-free conditions and inunfamiliar environments, so no cocaine-associated stimuli were presented. The cocaine-withdrawnmice showed cognitive deficits in spontaneous alternation behavior and place recognition memory.Importantly, they also displayed hyperlocomotion, increased rearing activity and altered exploratorypatterns in different tasks. In the forced swimming test, they were more active (struggled/climbedmore) when trying to escape from the water albeit showing similar immobility behavior thancontrols. In conclusion, in addition to cognitive deficits, chronic cocaine may induce lasting changesin psychomotor activation even in unfamiliar environments not associated to the drug. This outcomemay be influenced by factors related to exploration, energy or emotionality.
YR 2021
FD 2021
LK https://hdl.handle.net/10630/22817
UL https://hdl.handle.net/10630/22817
LA eng
NO 49th Meeting of the European Brain and Behaviour Society (EBBS)
NO PSI2017-82604; PRE2018-085673; I Plan Propio de Investigación, Transferencia y Divulgación Científica de la Universidad de Málaga
NO Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 13 abr 2026