RT Journal Article
T1 SENS vs. the hallmarks of aging: competing visions, shared challenges
A1 García-Barranquero, Pablo
A1 Pérez-González, Saúl
K1 Envejecimiento
K1 Gerontología
AB Aging research is often framed within pluralistic frameworks that emphasize cellular and molecular damage processes. Among the most influential are Strategies for Engineered Negligible Senescence (SENS), which aims to counteract biological decline through targeted damage repair, and the Hallmarks of Aging (HoA), which seeks to identify fundamental mechanisms underlying this process. Both proposals, although diverse, significantly influence contemporary approaches to the challenges posed by aging. However, despite extensive discussion, we contend that key conceptual and methodological aspects remain insufficiently explored. This paper seeks to advance the debate by critically analyzing and comparing their foundational goals, theoretical premises, and research frameworks. Specifically, we examine their definitions of aging, perspectives on health and disease, approaches to scientific evidence and causal interventions, and communications strategies. In doing so, we aim to contribute to a deeper understanding and more nuanced assessment of both SENS and the HoA.
PB Springer Nature
YR 2025
FD 2025-05-05
LK https://hdl.handle.net/10630/38654
UL https://hdl.handle.net/10630/38654
LA eng
NO García-Barranquero, P., Pérez-González, S. SENS vs. the hallmarks of aging: competing visions, shared challenges. Biogerontology 26, 103 (2025). https://doi.org/10.1007/s10522-025-10248-5
NO Funding for open access publishing: Universidad de Málaga/CBUA. Research funding was provided by Spanish Ministry of Science and Innovation (PID2021-125936NB-I00, PID2021-128835NB-I00, PID2022-137953OB-I00, and PID2023-149342NB-I00) and Valencian Department of Education, Universities, and Employment (CIGE/2023/16). Funding for open access charge was provided by University of Malaga / CBUA.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026