RT Journal Article
T1 Treatment with a non-toxic, self-replicating anti-prion delays or prevents prion disease in vivo.
A1 Diaz-Espinoza, R.
A1 Morales, Rodrigo
A1 Concha-Marambio, Luis
A1 Moreno-González, Inés
A1 Moda, Fabio
A1 Soto, Claudio
K1 Enfermedades por proteínas
AB Transmissible spongiform encephalopathies (TSEs) are fatal neurological disorders caused by prions, which are composed of a misfolded protein (PrP Sc) that self-propagates in the brain of infected individuals by converting the normal prion protein (PrP C) into the pathological isoform. Here, we report a novel experimental strategy for preventing prion disease based on producing a self-replicating, but innocuous PrP Sc -like form, termed anti-prion, which can compete with the replication of pathogenic prions. Our results show that a prophylactic inoculation of prion-infected animals with an anti-prion delays the onset of the disease and in some animals completely prevents the development of clinical symptoms and brain damage. The data indicate that a single injection of the anti-prion eliminated ∼99% of the infectivity associated to pathogenic prions. Furthermore, this treatment caused significant changes in the profile of regional PrP Sc deposition in the brains of animals that were treated, but still succumbed to the disease. Our findings provide new insights for a mechanistic understanding of prion replication and support the concept that prion replication can be separated from toxicity, providing a novel target for therapeutic intervention.
PB Springer Nature
YR 2018
FD 2018
LK https://hdl.handle.net/10630/37107
UL https://hdl.handle.net/10630/37107
LA eng
NO Diaz-Espinoza, Morales, Concha-Marambio, Moreno-Gonzalez, Moda, & Soto. (2018). Treatment with a non-toxic, self-replicating anti-prion delays or prevents prion disease in vivo. Molecular Psychiatry, 23(3),
NO https://openpolicyfinder.jisc.ac.uk/id/publication/24214
NO National Institute of Allergy and Infectious Diseases United States P01AI106705 to CS.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 22 ene 2026