RT Journal Article
T1 A combination of chain and neurophilic migration involving the adhesion molecule TAG-1 in the caudal medulla.
A1 Kyriakopoulou, Katerina
A1 De-Diego-Barbado, Isabel
A1 Wassef, Marion
A1 Karagogeos, Domna
K1 Embriología
K1 Glucoproteínas
K1 Médula espinal
K1 Desarrollo neurológico
AB TAG-1 está involucrada en la emigración de elas células destinadas a los núcleos precerebelares durante el desarrollo embrionario
AB Neuronal populations destined to form several precerebellar nuclei are generated by the rhombic lip in the caudal hindbrain. These immature neurons gather into the olivary and the superficial migratory streams and migrate tangentially around the hindbrain to reach their final position. We focus on the cells of the superficial stream that migrate ventrally, cross the midline and form the lateral reticular (LRN) and external cuneate (ECN) nuclei. The cells of the superficial steam are preceded by long leading processes; in the dorsal neural tube, they migrate in close apposition to each other and form distinct chains, whereas they disperse and follow Tuj-1 immunoreactive axons on reaching the ventral hindbrain. This suggests that, in the superficial stream, neuronal migration combines both homotypic and heterotypic mechanisms. We also show that the adhesion molecule TAG-1 is expressed by the migrating cells. Blocking TAG-1 function results in alterations in the superficial migration, indicating that TAG-1 is involved in the superficial migration. Other members of the immunoglobulin superfamily and known ligands of TAG-1 are also expressed in the region of the migration but are not involved in the migration. These findings provide evidence that the TAG-1 protein is involved as a contact-dependent signal guiding not only axonal outgrowth but also cell migration.
PB Wiley
YR 2002
FD 2002-01-15
LK https://hdl.handle.net/10630/41197
UL https://hdl.handle.net/10630/41197
LA eng
NO Katerina Kyriakopoulou, Isabel de Diego, Marion Wassef, Domna Karagogeos; A combination of chain and neurophilic migration involving the adhesion molecule TAG-1 in the caudal medulla. Development 15 January 2002; 129 (2): 287–296. doi: https://doi.org/10.1242/dev.129.2.287
NO https://openpolicyfinder.jisc.ac.uk/id/publication/14668
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 4 mar 2026