RT Journal Article
T1 Incidence of recently acquired hepatitis C virus infection among HIV-infected patients in southern Spain.
A1 González-Serna, A.
A1 Macías, Juan
A1 Palacios-Muñoz, María Rosario
A1 Gómez Ayerbe, Cristina
A1 Téllez-Rico, Francisco Javier
A1 Rivero-Juárez, Antonio
A1 Fernández, M.
A1 Santos-González, Jesús Leandro
A1 Real-Navarrete, Luis Miguel
A1 González-Doménech, Carmen María
A1 Gómez-Mateos, J.
A1 Pineda, Juan Antonio
A1 HEPAVIR study group, 
K1 Virus de la hepatitis C
K1 SIDA
K1 Homosexuales
AB Objectives: Spain is close to HCV microelimination, so rates of recently acquired HCV infection (RAHC) should decrease. Nowadays, men who have sex with men (MSM) carry the highest risk of HCV acquisition. Our aim was to estimate the incidence of and the factors associated with RAHC, together with reinfection rates, among patients sexually infected by HIV.Methods: Primary RAHC infection was diagnosed when anti-HCV antibody seroconversion was documented. In anti-HCV positive patients, initially without HCV viraemia, a diagnosis of reinfection was established if plasma HCV RNA was detected.Results: All 350 patients tested negative for anti-HCV at baseline and had at least one follow-up visit. Among them, there were 16 RAHC cases from 2016 to 2019. RAHC incidence rates [IR (95% confidence interval, CI)] per 100 person-years were 3.77 (0.5-12.9) in 2016, 1.85 (0.6-4.3) in 2017, 1.49 (0.4-3.8) in 2018 and 1.98 (0.6-4.5) in 2019. Only previous sexually transmitted infections [incidence rate ratio (IRR) = 18.23, 95% CI: 1.93-172.1; P = 0.011], male sex (IRR = 8.33, 95% CI: 1.38-54.15; P = 0.026) and sharing chem-sex drugs (IRR: 4.93, 95% CI: 1.17-20.76; P = 0.030), were independently associated with RAHC. Four out of 42 (9.5%) patients became reinfected. Conclusions: The incidence of RAHC among HIV-infected patients showed a decrease after 2016, although a lower but steady incidence of residual cases still remains. HCV reinfections showed a similar pattern. New infections were associated with sharing chem-sex drugs among MSM.
YR 2020
FD 2020-12-26
LK https://hdl.handle.net/10630/28968
UL https://hdl.handle.net/10630/28968
LA eng
NO Incidence of recently acquired hepatitis C virus infection among HIV-infected patients in southern Spain.
NO This study was partly supported by grants from the Ministerio de Economía, Industria y competitividad, Instituto de Salud Carlos III (grant no. PI15/01124) and from Grupo de Estudio de Hepatitis Vírica-SEIMC (grant no. GEHEP-001). AG-S and AR-J are recipients of Miguel Servet Research Contracts by the Ministerio de Ciencia, Promoción y Universidades of Spain (CP18/00146; CP18/00111). JM is the recipient of a grant from the Servicio Andaluz de Salud de la Junta de Andalucía (grant no. B-0037). JAP is recipient of an intensification grant from the Instituto de Salud Carlos III (grant no. Programa-I3SNS).
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 21 ene 2026