RT Journal Article
T1 Smoking exacerbates amyloid pathology in a mouse model of Alzheimer’s disease
A1 Moreno-Gonzalez, Ines
A1 Estrada, Lisbell D
A1 Sánchez-Mejías, Elisabeth
A1 Soto, Claudio
K1 Alzheimer, Enfermedad
K1 Tabaco -- Consumo
K1 Enfermedades -- Modelos animales
K1 Amiloide
AB Several epidemiological studies have shown that cigarette smoking might alter the incidence of Alzheimer’s disease. However, inconsistent results have been reported regarding the risk of Alzheimer’s disease among smokers. Previous studies in experimental animal models have reported that administration of some cigarette components (for example, nicotine) alters amyloid-b aggregation, providing a possible link. However, extrapolation of these findings towards the in vivo scenario is not straightforward as smoke inhalation involves a number of other components. Here, we analysed the effect of smoking under more relevant conditions. We exposed transgenic mouse models of Alzheimer’s disease to cigarette smoke and analysed the neuropathological alterations in comparison with animals not subjected to smoke inhalation. Our results showed that smoking increases the severity of some abnormalities typical of Alzheimer’s disease, including amyloidogenesis, neuroinflammation and tau phosphorylation. Our findings suggest that cigarette smoking may increase Alzheimer’s disease onset and exacerbate its features and thus, may constitute an important environmental risk factor for Alzheimer’s disease.
PB Macmillan Publishers Limited
YR 2013
FD 2013-02
LK https://hdl.handle.net/10630/34303
UL https://hdl.handle.net/10630/34303
LA eng
NO Moreno-Gonzalez, I., Estrada, L., Sanchez-Mejias, E. et al. Smoking exacerbates amyloid pathology in a mouse model of Alzheimer’s disease. Nat Commun 4, 1495 (2013).
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 23 abr 2026