RT Journal Article
T1 Taxonomic and functional characteristics of the gut microbiota in obesity: A systematic review
A1 Díaz Perdigones, Cristina María
A1 Hinojosa-Nogueira, Daniel
A1 Rodríguez-Muñoz, Alba
A1 Subiri-Verdugo, Alba
A1 Vilches-Pérez, Alberto
A1 Mela, Virginia
A1 Tinahones-Madueño, Francisco José
A1 Moreno-Indias, Isabel
K1 Diversidad microbiana
K1 Metabolismo
K1 Obesidad
AB Obesity is a growing public health problem. In recent decades, scientific evidence haslinked gut microbiota to obesity. This systematic review summarizes current knowledge on thecomposition and functional differences in gut microbiota between individuals with obesity andthose with normal weight. Following PRISMA 2020 recommendations, studies published in adultpopulations between January 2014 and May 2024 were reviewed. PubMed, Web of Science, andScopus databases were searched for observational studies that had used advanced sequencingmethods, such as 16S rRNA and shotgun metagenomics, to assess gut microbiota. The qualityof these studies was also analyzed using the Newcastle-Ottawa scale. Our review of 16 studiesshows a reduction in microbial diversity in individuals with obesity. In addition, a higher relativeabundance of the phylum Firmicutes, the families Enterobacteriaceae, Gemellaceae, Prevotellaceae, Streptococcaceae and Veillonellaceae, as well as the genera Blautia, Butyricimonas,Collinsella, Megamonas, and Streptococcus, while beneficial bacteria such as the familiesPorphyromonadaceae and Rikenellaceae, and the genera Bifidobacterium spp. and Faecalibacterium prausnitzii, were depleted. Functional analysis showed a tendency to an increase inmetabolic pathways associated with carbohydrate and lipid metabolism, with reduced pathwaysrelated to short-chain fatty acid production. Obesity is associated with altered gut microbiotacomposition and function. However, the variability across studies regarding population characteristics, dietary pattern, and sequencing techniques limits the comparability of findings. Futureresearch should prioritize standardized methodologies and confounding factors to elucidate therole of the gut microbiome in obesity
AB La obesidad supone un problema creciente de salud pública debido a su prevalencia. En las últimas décadas, la evidencia científica ha relacionado la microbiota intestinalcon la obesidad. Esta revisión sistemática resume los conocimientos sobre la composición yfuncionalidad de microbiota intestinal en personas con obesidad frente a los de peso normal.Siguiendo las recomendaciones de PRISMA 2020, se revisaron los estudios publicados entre enerode 2014 y mayo de 2024, en poblaciones adultas. Se buscaron en las bases de datos PubMed,Web of Science y Scopus estudios observacionales que hubieran utilizado métodos avanzadosde secuenciación, como ARNr 16S y shotgun metagenomics, y fueron evaluados mediante laescala Newcastle-Ottawa. Nuestra revisión de 16 estudios expone una reducción de la diversidad microbiana en los individuos con obesidad. Además, una mayor abundancia relativa del filoFirmicutes, las familias Enterobacteriaceae, Gemellaceae, Prevotellaceae, Streptococcaceae yVeillonellaceae, así como los géneros Blautia, Butyricimonas, Collinsella, Megamonas, y Streptococcus, mientras que las familias beneficiosas Porphyromonadaceae y Rikenellaceae, así comolos géneros Bifidobacterium spp y Faecalibacterium prausnitzii estaban mermados. El análisisfuncional parece indicar un aumento de las vías metabólicas asociadas al metabolismo de loshidratos de carbono y los lípidos, con reducción de vías relacionadas con la producción de ácidosgrasos de cadena corta. La obesidad se asocia con alteraciones en la composición y funcionalidad de la microbiota intestinal. La heterogeneidad entre estudios limita la comparabilidad, porlo que se recomienda estandarizar metodologías en futuras investigaciones
PB Elsevier
YR 2025
FD 2025-04
LK https://hdl.handle.net/10630/39958
UL https://hdl.handle.net/10630/39958
LA eng
NO C.M. Díaz Perdigones, D. Hinojosa Nogueira, A. Rodríguez Munoz ˜ et al., Taxonomic and functional characteristics of the gut microbiota in obesity: A systematic review, Endocrinología, Diabetes y Nutrición, https://doi.org/10.1016/j.endinu.2025.501624
NO This study has been funded by the Instituto de Salud CarlosIII (ISCIII) through projects (PI18/01160) and (PI21/01677)and co-funded by the European Union. F.J.T. and I.M.-I.also obtained the UMA-FEDERJA-116 project, financed by theAndalusian Regional Government and co-financed with ERDFfunds. In addition, C.M.D.-P. was supported by a Rio Hortega postdoctoral contract (CM23/00128) from ISCIII-Madrid(Spain) and D.H.-N. was supported by a Sara Borrell postdoctoral contract (CD23/00111) from ISCIII-Madrid (Spain).A.S.-V. was supported by a predoctoral PFIS (FI22/00193)from ISCIII-Madrid (Spain). V.M. was supported by the ‘MiguelServet’ programme (CP22/00033) ofthe ISCIII-Madrid (Spain)and I.M.-I. was supported by the ‘Miguel Servet Type II’ programme (CPII21/00013) of the ISCIII-Madrid (Spain).
NO Funding for open access charge: Universidad de Málaga / CBUA
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026