RT Conference Proceedings
T1 Anti-inflammatory potential of aeroplysinin-1, a bioactive compound isolated from the sponge Aplysina aerophoba
A1 Bravo-Ruiz, Inés
A1 Bernal, Manuel
A1 Manrique-Poyato, Maria Inmaculada
A1 Rodríguez-Quesada, Ana María
A1 Medina-Torres, Miguel Ángel
A1 Castilla, Laura
A1 Martínez-Póveda, Beatriz Amparo
K1 Medicamentos - Congresos
AB Aeroplysinin-1 (Apl-1) is a brominated compound isolated from the marine sponge Aplysina aerophoba that has been shown to possess bioactive effects with a broad spectrum of action in in vitro and in vivo assays. Included in its pleiotropic activity are anti-tumor, anti-angiogenic, pro-apoptotic [1] and anti-oxidant effects [2], making Apl-1 a natural compound with very promising properties for its use as a potential therapeutic agent. In addition to the aforementioned effects, our group explored the role of Apl-1 in inflammation, a process related to numerous highly prevalent pathologies, such as cancer and atherosclerosis, showing the first evidence of its anti-inflammatory potential [3]. In this work, our group delves into the anti-inflammatory effect of Apl-1 in the context of vascular endothelium and provides new data regarding the molecular mechanism underlying this activity. The characterization of the mechanism of action points to the modulatory effect of Apl-1 on pathways involved in endothelial activation during the development of inflammation, experimental evidence that opens the door to the potential use of this compound as an anti-inflammatory agent.
PB 43 Congreso Anual SEBBM
YR 2021
FD 2021
LK https://hdl.handle.net/10630/22856
UL https://hdl.handle.net/10630/22856
LA eng
NO Contribución a Congreso (póster)
NO Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech. This work is supported by funds from projects PID2019-105010RB-100 (Ministry of Science, Government of Spain), UMA18-FEDERJA-220 (Junta de Andalucía and FEDER funds), and funds from the BIO-267 group (Junta de Andalucía). M.B. is supported by a Juan de la Cierva fellowship (Government of Spain).
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026