RT Journal Article
T1 The Development of the Bengamides as New Antibiotics against Drug-Resistant Bacteria
A1 Porras Alcalá, Cristina
A1 Moya-Utrera, Federico
A1 García-Castro, Miguel
A1 Sánchez-Ruiz, Antonio
A1 López-Romero, Juan Manuel
A1 Pino-González, María Soledad
A1 Díaz-Morilla, Amelia
A1 Kitamura, Seiya
A1 W. Wolan, Dennis
A1 Prados, Jose
A1 Melguizo, Consolación
A1 Cheng-Sánchez, Iván
A1 Sarabia-García, Francisco Ramón
K1 Antibióticos
AB The bengamides comprise an interesting family of natural products isolated from sponges belonging to the prolific Jaspidae family. Their outstanding antitumor properties, coupled with their unique mechanism of action and unprecedented molecular structures, have prompted an intense research activity directed towards their total syntheses, analogue design, and biological evaluations for their development as new anticancer agents. Together with these biological studies in cancer research, in recent years, the bengamides have been identified as potential antibiotics by their impressive biological activities against various drug-resistant bacteria such as Mycobacterium tuberculosis and Staphylococcus aureus. This review reports on the new advances in the chemistry and biology of the bengamides during the last years, paying special attention to their development as promising new antibiotics. Thus, the evolution of the bengamides from their initial exploration as antitumor agents up to their current status as antibiotics is described in detail, highlighting the manifold value of these marine natural products as valid hits in medicinal chemistry.
PB IOAP-MPDI
YR 2022
FD 2022-05-31
LK https://hdl.handle.net/10630/24485
UL https://hdl.handle.net/10630/24485
LA eng
NO Porras-Alcalá C, Moya-Utrera F, García-Castro M, Sánchez-Ruiz A, López-Romero JM, Pino-González MS, Díaz-Morilla A, Kitamura S, Wolan DW, Prados J, Melguizo C, Cheng-Sánchez I, Sarabia F. The Development of the Bengamides as New Antibiotics against Drug-Resistant Bacteria. Marine Drugs. 2022; 20(6):373. https://doi.org/10.3390/md20060373
NO Supported by grants RTI2018-098296-BI00 (Ministerio de Ciencia e Innovación), PI19/01478 from Instituto de Salud Carlos III (ISCIII) (FEDER), P20_00540 (Andalusian Government and FEDER), K99GM138758 and R35GM136286 (National Institute of General Medical Sciences of the National Institutes of Health), A-CTS-666-UGR20 (University of Granada) (FEDER), CTS-107 (Andalusian Government) and 2021-GRIN-30998 (University of Castilla-La Mancha). Partial funding for open access charge: Universidad de Málaga
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026