RT Conference Proceedings
T1 Is the bulbus arteriosus of fish homologous to the mamalian intrapericardial thoracic arteries?
A1 López‐García, Alejandro
A1 Fernández-Domínguez, María Carmen
A1 Fernández-Tamayo, Alejandro
A1 Durán-Boyero, Ana Carmen
A1 Fernández-Corujo, Borja
K1 Vertebrados - Corazón
AB Two major findings have significantly improved our understanding of theembryology and evolution of the arterial pole of the vertebrate heart (APVH): 1) anew embryonic presumptive cardiac tissue, named second heart field (SHF), formsthe myocardium of the outflow tract, and the walls of the ascending aorta (AA) andthe pulmonary trunk (PT) in mammals and birds; 2) the bulbus arteriosus (BA),previously thought to be an actinopterygian apomorphy, is present in all basalVertebrates, and probably derives from the SHF. We hypothesized that theintrapericardial portions of the AA and the PT of mammals are homologous to theBA of basal vertebrates. To test this, we performed 1) a literature review of theanatomy and embryology of the APVH; 2) novel anatomical, histomorphological,and embryological analyses of the APVH, comparing basal (Galeus atlanticus), withapical (Mus musculus and Mesocricetus auratus) vertrebrates. Evidence obtained:1) Anatomically, BA, AA, and PT are muscular tubes into the pericardial cavity,which connect the distal myocardial outflow tracts with the aortic arch system.Coronary arteries run through or originate at these anatomical structures; 2)Histologically, BA, AA, and PT show an inner layer of endothelium covered bycircumferentially oriented smooth muscle cells, collagen fibers, and lamellarelastin. The histomorphological differences between the BA and the ventral aortaparallel those between intrapericardial and extrapericardial great arteries; 3)Embryologically, BA, AA, and PT are composed of smooth muscle cells derivedfrom the SHF. They show a similar mechanism of development: incorporation ofSHF‐derived cells into the pericardial cavity, and distal‐to‐proximal differentiationinto an elastogenic cell linage.In conclusion, anatomical, histological and embryological evidence supports thehypothesis that SHF is a developmental unit responsible for the formation of theAPVH. The BA and the intrapericardial portions of the great arteries must beconsidered homologous structures.
YR 2013
FD 2013-07-26
LK http://hdl.handle.net/10630/5660
UL http://hdl.handle.net/10630/5660
LA eng
NO El resumen aparece en el Program & Abstracts of the 10th International Congress of Vertebrate Morphology, Barcelona 2013.Anatomical Record, Volume 296, Special Feature — 1: P-089.
NO Proyecto P10-CTS-6068 (Junta de Andalucía); proyecto CGL-16417 (Ministerio de Ciencia e Innovación); Fondos FEDER.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026