RT Journal Article
T1 Differential behavior of serum and red blood cell folate during a treatment with levofolinic acid. Gender differences.
A1 Lendínez Ramírez, Ana María
A1 Reyes Palomares, Arturo Lazaro
A1 Pérez Nevot, Beatriz
A1 Cortés Rodríguez, Miriam
A1 Ruiz-Galdón, Maximiliano
A1 Reyes-Engel, Armando
K1 Eritrocitos
K1 Acido folínico - Uso terapéutico
K1 Diferencias sexuales
AB Background: Folates are essential nutrients that maintain nucleotide synthesis and methylation reactions. Folate levels depend essentially on the diet. In the present work, the changes in the folate-homocysteine (Hcy) metabolic axis were studied in response to treatment with levofolinic acid.Methods: 49 college students (23 men and 26 women) underwent a treatment voluntarily with 5 mg/day levofolinic acid for one month. Serum and red blood cell folate, vitamin B12, and Hcy levels were determined on days 2, 5, 10, and 30 during treatment and 30 days after completion of treatment.Results: Serum folate and Hcy levels showed a plateau beginning on day 10, while red blood cell folate increased towards treatment completion. Gender differences were found in basal levels of Hcy, these differences remaining until the 10th day of treatment and reappearing 30 days after the treatment was finished. Between gender differences in treatment evolution were found only in percentage changes in red blood cell folate in women and men at day 30 of treatment.Conclusions: There is a compartmentalization of folates in the body that presents a plateau in serum and an erythrocyte reservoir. Folate metabolism presents differential features between genders. The greater physiological need for folate in women of childbearing age could be the determining factor in this difference.
PB Clinical Laboratory Publications
YR 2014
FD 2014-01-01
LK https://hdl.handle.net/10630/37570
UL https://hdl.handle.net/10630/37570
LA spa
NO Lendinez AM, Palomares AR, Perez-Nevot B, Cortés Rodríuez M, Ruiz-Galdon M, Reyes-Engel A. Differential behavior of serum and red blood cell folate during a treatment with levofolinic acid. Gender differences. Clin Lab. 2014;60(9):1579-84. doi: 10.7754/clin.lab.2013.130914. PMID: 25291957.
NO It is a condition of publication that authors assign copyright or license the publication rights, including summaries, to Clinical Laboratory Publications GmbH. Authors may, of course, use the article elsewhere after publication without prior permission from Clinical Laboratory Publications GmbH, provided that acknowledgment is given to the journal as the original source of publication, and that Clinical Laboratory Publications GmbH is notified so that our records show that its use is properly authorized.https://www.clin-lab-publications.com/author-guide
NO This study was supported by the “Ministerio de Educación y Ciencia” (Spain), (SAF2008-03314) and “Programa Torres Quevedo” (PTQ-09-0100496) Grants.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 21 ene 2026