RT Journal Article
T1 Systematic review: ibuprofen-induced liver injury.
A1 Zoubek, Miguel E.
A1 Lucena-González, María Isabel
A1 Andrade-Bellido, Raúl Jesús
A1 Stephens, Camilla
K1 Hepatotoxicidad
K1 Hígado - Heridas y lesiones
K1 Ibuprofeno - Efectos secundarios
K1 Revisiones sistemáticas (Medicina)
AB Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) are a leading cause ofdrug-induced liver injury (DILI) across the world. Ibuprofen is one of the most commonlyused and safest NSAIDs, nevertheless reports on ibuprofen-induced hepatotoxicity areavailable.Aim: To analyse previously published information on ibuprofen-induced liver injury fora better characterisation of its phenotypic expression.Method: A systematic search was performed and information on ibuprofen-induced liverinjury included in case series and case reports, in terms of demographic, clinical,biochemical and outcome data, was analysed.Results: Twenty-two idiosyncratic ibuprofen hepatotoxicity cases were identified in theliterature, suggesting a very low prevalence of this type of DILI. These patients had amean age of 31 years and 55% were females. Mean cumulative dose of ibuprofen andtime to onset were 30 g and 12 days, respectively. Hepatocellular injury was the mostfrequently involved liver injury pattern. Six cases developed vanishing bile ductsyndrome. Full recovery occurred in 11 patients after a mean time of 14 weeks, whereasfive cases evolved to acute liver failure leading to death/liver transplantation.Conclusions: When assessing potential hepatotoxicity cases, physicians should keep inmind that ibuprofen has been associated with hepatotoxicity in the literature. Ibuprofenassociated DILI presents commonly as hepatocellular damage after a short latency period.Published reports on ibuprofen hepatotoxicity leading to liver failure resulting in livertransplantation or death are available. However, due to the apparent low absolute risk ofibuprofen-induced liver complications, ibuprofen can be regarded as an efficacious andsafe NSAID.
PB Wiley-Blackwell
YR 2020
FD 2020-01-27
LK https://hdl.handle.net/10630/40285
UL https://hdl.handle.net/10630/40285
LA eng
NO Miguel E Zoubek, María Isabel Lucena, Raúl J Andrade, Camilla Stephens. Systematic review: ibuprofen-induced liver injury. Aliment Pharmacol Ther 2020 Mar;51(6):603-611
NO https://openpolicyfinder.jisc.ac.uk/id/publication/81
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026