RT Journal Article
T1 The high producer variant of the Fc-receptor like-3 (FCRL3) gene is involved in protection against multiple sclerosis.
A1 Matesanz, Fuencisla
A1 Fernández-Fernández, Óscar
A1 Milne, Roger L.
A1 Fedetz, María
A1 Leyva-Fernández, Laura
A1 Guerrero, Miguel
A1 Delgado, Concepción
A1 Lucas, Miguel
A1 Izquierdo, Guillermo
A1 Alcina, Antonio
K1 Esclerosis múltiple
AB Some polymorphisms in the FCRL3 gene, a member of the Fc-receptor like family, have been associated with several autoimmune diseases and recently with multiple sclerosis (MS). We performed a case–control study of three SNPs in FCRL3 gene in 645 MS patients and 786 controls, all Caucasians from the South of Spain. Genotype and allele frequencies of two SNPs (rs7528684/FCRL3_3 and rs7522061/N28D), which were in high linkage disequilibrium (r2=0.87), differed between MS cases and controls. The C allele of FCRL3_3 was found to be protective for MS (per allele OR=0.81, 95% C.I.=0.70–0.94; P-value=0.007) as was the G variant of N28D, but no association was found for rs11264799/FCRL3_4.Haplotype analysis confirmed these associations with highly consistent effect sizes for haplotypes carrying the C allele of FCRL3_3.
PB Elsevier
YR 2008
FD 2008
LK https://hdl.handle.net/10630/37020
UL https://hdl.handle.net/10630/37020
LA eng
NO Matesanz F, Fernández O, Milne RL, Fedetz M, Leyva L, Guerrero M, Delgado C, Lucas M, Izquierdo G, Alcina A. The high producer variant of the Fc-receptor like-3 (FCRL3) gene is involved in protection against multiple sclerosis. J Neuroimmunol 2008 Mar;195(1-2):146-50. Epub 2008 Mar 3. PMID: 18313765
NO Artículo J Neuroimmunol 2008 Mar;195(1-2):146-50.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026