RT Journal Article
T1 Preservation of renal function in cardiac surgery patients with low cardiac output syndrome: levosimendan vs beta agonists.
A1 Guerrero-Orriach, José Luis
A1 Navarro Arce, Isabel
A1 Hernandez Rodriguez, P
A1 Raigón Ponferrada, Aída
A1 Malo Manso, A
A1 Ramirez Aliaga, M
A1 Ramirez Fernandez, A
A1 Escalona Belmonte, JJ
A1 Bellido-Estévez, Inmaculada
A1 Gómez-Luque, José Aurelio
A1 Barrera Serrano, R
A1 Toledo Medina, CS
A1 Rubio-Navarro, Manuel
A1 Cruz Mañas, J
K1 Corazón - Cirugía
AB Background Some studies have been performed to assess the effects of levosimendan on cardiac function when administered to cardiac surgery patients with low cardiac output syndrome (LCOS) in the immediate postoperative period. Levosimendan is an inotropic agent for the treatment of low cardiac output syndrome that seems to have a protective effect on renal function.Methods It is a quasi-experimental study. A total of 100 patients with LCOS received either beta-agonists or levosimendan. We assessed the incidence of postoperative kidney failure in cardiac surgery patients. In patients who had kidney failure at diagnosis of LCOS, we examined whether differences existed in the evolution of kidney failure based on the treatment administered for LCOS. The parameters measured included haemodynamics, oxygen supply, and renal function as assessed by the AKI scale. ANOVA, Student’s t-test and Wilcoxon or Friedman tests were used.Results Up to 30% of cardiac surgery patients had kidney failure at diagnosis of LCOS. Kidney failure at discharge from the ICU was more frequent in patients who received beta-agonist drugs as compared to those who received levosimendan (p < 0.05).Conclusion The incidence of kidney failure decreased with the postoperative administration of levosimendan to cardiac surgery patients with LCOS, as compared to beta-agonists.Trial registration Current Controlled Trials ISRCTN 46058317. Date of registration: 7/10/2019.
PB Springer Nature
YR 2019
FD 2019-11-17
LK https://hdl.handle.net/10630/36657
UL https://hdl.handle.net/10630/36657
LA eng
NO Guerrero Orriach, J., Navarro Arce, I., Hernandez Rodriguez, P. et al. Preservation of renal function in cardiac surgery patients with low cardiac output syndrome: levosimendan vs beta agonists. BMC Anesthesiol 19, 212 (2019). https://doi.org/10.1186/s12871-019-0888-2
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 23 ene 2026