RT Journal Article
T1 Brain structural and functional correlates of the heterogenous progression of mixed transcortical aphasia
A1 López-Barroso, Diana
A1 Paredes-Pacheco, José
A1 Torres-Prioris, María José
A1 Dávila-Arias, María Guadalupe
A1 Berthier-Torres, Marcelo Luis
K1 Neurología
K1 Afasia
AB Mixed transcortical aphasia (MTCA) is characterized by non-fluent speech and comprehension deficits coexisting with preserved repetition. MTCA may evolve to less severe variants of aphasias or even to full language recovery. Mechanistically, MCTA has traditionally been attributed to a disconnection between the spared left perisylvian language network (PSLN) responsible for preserved verbal repetition, and damaged left extrasylvian networks, which are responsible for language production and comprehension impairments. However, despite significant advances in in vivo neuroimaging, the structural and functional status of the PSLN network in MTCA and its evolution has not been investigated. Thus, the aim of the present study is to examine the status of the PSLN, both in terms of its functional activity and structural integrity, in four caseswho developed acute post-stroke MTCA and progressed to different types of aphasia. For it, we conducted a neuroimaging-behavioral study performed in the chronic stage of four patients. The behavioral profile of MTCA persisted in one patient,whereas the other three patients progressed to less severe types of aphasias. Neuroimaging findings suggest that preservedverbal repetition in MTCA does not always depend on the optimal status of the PSLN and its dorsal connections. Instead, theright hemisphere or the left ventral pathway may also play a role in supporting verbal repetition. The variability in the clinicalevolution of MTCA may be explained by the varying degree of PSLN alteration and individual premorbid neuroanatomicallanguage substrates. This study offers a fresh perspective of MTCA through the lens of modern neuroscience and unveilsnovel insights into the neural underpinnings of repetition.
PB Springer
YR 2023
FD 2023
LK https://hdl.handle.net/10630/26929
UL https://hdl.handle.net/10630/26929
LA eng
NO López-Barroso, D., Paredes-Pacheco, J., Torres-Prioris, M.J. et al. Brain structural and functional correlates of the heterogenous progression of mixed transcortical aphasia. Brain Struct Funct 228, 1347–1364 (2023). https://doi.org/10.1007/s00429-023-02655-6
NO Funding for open access publishing: Universidad Málaga/CBUA. This work was supported by the Spanish Ministry of Economy, Industry and Competitiveness, Instituto de Salud Carlos III underGrant: PI16/01514 (MLB and GD) and by the Junta de Andalucía under Grant: P20_00501 (GD). MLB was funded by the European Social Fund (FEDER). DL-B was supported by the Ayuda RYC2020-029495-I Ramón y Cajal funded by the MCIN/AEI/10.13039/501100011033 and by El FSE invierte en tu futuro; and by the Grant PID2021-127617NA-I00 Proyecto de Generación de Conocimiento 2021 funded by MCIN/AEI /10.13039/501100011033/ and FEDER Una manera de hacer Europa. JP-P was funded by a PhD scholarship (FPU16/05198) from the Spanish Ministry of Education, Culture and Sport under the FPUprogram. MJT-P was supported by a Margarita Salas postdoctoral fellowship by the University of Malaga, funded by the European Union– NextGenerationEU – and the Spanish Ministerio de Universidades, and by a mobility grant from the Spanish Ministry of Universities under the José Castillejo program.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026