RT Journal Article
T1 GLS and GLS2 Glutaminase Isoenzymes in the Antioxidant System of Cancer Cells.
A1 De los Santos-Jiménez, Juan
A1 Campos-Sandoval, José Ángel
A1 Alonso-Carrión, Francisco José
A1 Márquez-Gómez, Javier
A1 Mates-Sánchez, José Manuel
K1 Isoenzimas
K1 Estrés oxidativo
K1 Células - Metabolismo
K1 Cáncer - Aspectos moleculares
AB A pathway frequently altered in cancer is glutaminolysis, whereby glutaminase (GA)catalyzes the main step as follows: the deamidation of glutamine to form glutamate and ammonium.There are two types of GA isozymes, named GLS and GLS2, which differ considerably in theirexpression patterns and can even perform opposing roles in cancer. GLS correlates with tumor growthand proliferation, while GLS2 can function as a context-dependent tumor suppressor. However,both isoenzymes have been described as essential molecules handling oxidant stress because of theirinvolvement in glutathione production. We reviewed the literature to highlight the critical roles ofGLS and GLS2 in restraining ROS and regulating both cellular signaling and metabolic stress due totheir function as indirect antioxidant enzymes, as well as by modulating both reductive carboxylationand ferroptosis. Blocking GA activity appears to be a potential strategy in the dual activation offerroptosis and inhibition of cancer cell growth in a ROS-mediated mechanism.
PB MDPI
YR 2024
FD 2024-06-20
LK https://hdl.handle.net/10630/31797
UL https://hdl.handle.net/10630/31797
LA eng
NO De los Santos-Jiménez, J.; Campos-Sandoval, J.A.; Alonso, F.J.; Márquez, J.; Matés, J.M. GLS and GLS2 Glutaminase Isoenzymes in the Antioxidant System of Cancer Cells. Antioxidants 2024, 13, 745. https:// doi.org/10.3390/antiox13060745
NO This research was funded by the Ministerio de Ciencia e Innovación of Spain, grant number: PID2022-140388OB-I00
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026