RT Journal Article T1 An integrated biorefinery approach based on spent coffee grounds valorization A1 Pérez-Merchán, Antonio Manuel A1 Moreno-Tost, Ramón A1 Malpartida-García, Irene A1 García-Sancho, Cristina A1 Mérida-Robles, Josefa María A1 Maireles-Torres, Pedro Jesús K1 Química verde K1 Desarrollo sostenible K1 Refinerías K1 Biomasa K1 Café AB Spent coffee grounds (SCGs) are an abundant lignocellulosic biomass with significant potential for industrialvalorization, with great social and environmental benefits, due to their rich composition in cellulose, hemicellulose and lignin. In this study, the organosolv process, a method widely used in the paper industry, wasemployed to efficiently fractionate SCGs into their primary components. Hemicellulosic liquors containing up to25 wt% sugars, predominantly galactose and mannose, were successfully extracted and subsequently dehydratedto produce 5-hydroxymethylfurfural (5-HMF), reaching a maximum yield of 90 % within 15 min of reaction time.The residual cellulose and lignin fractions were characterized by X-ray diffraction (XRD) and Fourier-transforminfrared spectroscopy (FTIR), confirming their effective separation. These findings highlight the viability of SCGsas a sustainable feedstock for biorefinery applications, contributing to waste valorization and the development ofa circular economy. PB Elsevier YR 2025 FD 2025 LK https://hdl.handle.net/10630/40497 UL https://hdl.handle.net/10630/40497 LA eng NO Pérez-Merchán AM, Moreno-Tost R, Malpartida-García I, García-Sancho C, Mérida-Robles JM, Maireles-Torres P. An integrated biorefinery approach based on spent coffee grounds valorization. Journal of Cleaner Production. 2025;528:146716. https://doi.org/10.1016/j.jclepro.2025.146716 NO Funding for open access charge: Universidad de Málaga/CBUA DS RIUMA. Repositorio Institucional de la Universidad de Málaga RD 21 ene 2026