RT Journal Article
T1 Use of human pluripotent stem cell-derived cells for neurodegenerative disease modeling and drug screening platform
A1 García-León, Juan Antonio
A1 Vitorica Ferrández, Javier
A1 Gutiérrez-Pérez, Antonia
K1 Alzheimer, Enfermedad de
AB Most neurodegenerative diseases are characterized by a complex and mostly still unresolved pathology. This fact, together with the lack of reliable disease models, has precluded the development of effective therapies counteracting the disease progression. The advent of human pluripotent stem cells has revolutionized the field allowing the generation of disease-relevant neural cell types that can be used for disease modeling, drug screening and, possibly, cell transplantation purposes. In this Review, we discuss the applications of human pluripotent stem cells, the development of efficient protocols for the derivation of the different neural cells and their applicability for robust in vitro disease modeling and drug screening platforms for most common neurodegenerative conditions
PB Taylor and Francis
YR 2019
FD 2019-06
LK https://hdl.handle.net/10630/34450
UL https://hdl.handle.net/10630/34450
LA eng
NO Garcia-Leon, J. A., Vitorica, J., & Gutierrez, A. (2019). Use of Human Pluripotent Stem Cell-Derived Cells for Neurodegenerative Disease Modeling and Drug Screening Platform. Future Medicinal Chemistry, 11(11), 1305–1322. https://doi.org/10.4155/fmc-2018-0520
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026